Effect of saffron on premenstrual syndrome and dysmenorrhea: a systematic review and meta-analysis.

IF 3.4 Q4 PRIMARY HEALTH CARE

Korean Journal of Family Medicine Pub Date : 2026-01-01 Epub Date: 2025-10-28 DOI:10.4082/kjfm.24.0259

Mohammad Mehdi Mohammadi, Zohreh Karimi

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Abstract

Background: Premenstrual syndrome (PMS) and dysmenorrhea are common symptoms in women. In this study, we investigated the effects of saffron on PMS and dysmenorrhea in women.

Methods: In this systematic review and meta-analysis, we comprehensively screened a range of databases, including PubMed, Web of Science, and Science Direct. We included randomized clinical trials investigating the effects of saffron on PMS or dysmenorrhea. Quality assessment of the identified studies was conducted using the Cochrane risk-of-bias assessment tool. Meta-analysis was performed using Comprehensive Meta-Analysis software ver. 2 based on the random effects model.

Results: Meta-analysis revealed that saffron had a significant positive effect on the symptoms of PMS in women (standardized mean difference [SMD], -0.64; 95% confidence interval [CI], -0.84 to -0.44). Furthermore, saffron was effective in reducing dysmenorrhea (SMD, -0.51; 95% CI, -1.01 to -0.01).

Conclusion: The findings of our meta-analysis indicate that saffron exerts beneficial effects on the symptoms of both PMS and dysmenorrhea in women.

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藏红花对经前期综合征和痛经的影响：系统综述和荟萃分析。

背景：经前综合征（PMS）和痛经是女性常见的症状。在本研究中，我们研究了藏红花对女性经前症候群和痛经的影响。方法：在本系统综述和荟萃分析中，我们全面筛选了一系列数据库，包括PubMed、Web of Science和Science Direct。我们纳入了调查藏红花对经前症候群或痛经影响的随机临床试验。使用Cochrane偏倚风险评估工具对已确定的研究进行质量评估。采用综合meta分析软件进行meta分析。2基于随机效应模型。结果：荟萃分析显示，藏红花对女性经前综合症的症状有显著的积极作用（标准化平均差[SMD]， -0.64； 95%可信区间[CI]， -0.84至-0.44）。此外，藏红花可有效减轻痛经（SMD, -0.51; 95% CI, -1.01至-0.01）。结论：我们的荟萃分析结果表明，藏红花对女性经前症候群和痛经症状都有有益的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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