Verification, Validation, and Uncertainty Quantification (VVUQ) of Physiologically Based Pharmacokinetic Models for Theranostic Digital Twins

IF 3.1 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

PET Clinics Pub Date : 2026-01-01 Epub Date: 2025-10-23 DOI:10.1016/j.cpet.2025.08.004

Nouran R.R. Zaid PhD , Deni Hardiansyah Dr.sc.hum , Tahir Yusufaly PhD , Arman Rahmim PhD, DABSNM

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验证，验证和不确定量化的基于生理的药代动力学模型为治疗数字双胞胎：迈向可靠的模型知情的治疗计划的放射性药物治疗。

基于生理的药代动力学（PBPK）模型为模拟放射性药物动力学和估计患者特异性吸收剂量提供了一个机制框架。PBPK模型结合了患者生理学和药物特异性的先验知识。PBPK模型最终可用于预测治疗反应，从而使放射药物治疗（RPTs）中个性化治疗计划的治疗数字双胞胎成为可能。然而，为了实现精确RPTs的潜力，必须通过严格的验证、确认和不确定性量化（VVUQ）来建立底层建模的可靠性。这篇综述概述了VVUQ在确保PBPK模型在放射治疗学中的可信度和临床适用性方面的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

PET Clinics RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

5.70

自引率

3.80%

发文量

期刊介绍： As the clinical applications of positron emission tomography (PET) increase, the new PET Clinics brings together the combined expertise of leading authorities in the field to provide you incisive clinical reviews on advances in the use of PET and combined PET/CT. Published quarterly, PET Clinics provides concise, practical guidance on the clinical issues you face every day. It examines PET is effectiveness in cancer diagnosis and staging, as well as exploring PET is usefulness in the areas of dementia, myocardial viability, and other conditions. Full-color images featured throughout. Topics covered include Breast Cancer, Alzheimer is Disease and Dementia, Lymphoma, Lung Cancer, Cardiology, Pediatric Applications, Infection and Inflammation.