Role of m⁶A mRNA Methylation in Plant Defense.

IF 4.1 Q3 GENETICS & HEREDITY

Epigenomes Pub Date : 2025-10-15 DOI:10.3390/epigenomes9040042

Rakesh Srivastava, Niraj Lodhi

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Abstract

N6-methyladenosine (m⁶A) is the most abundant and dynamic RNA modification in eukaryotic messenger and non-coding RNAs, playing a pivotal role in the post-transcriptional regulation of gene expression. The coordinated actions of m⁶A writers, erasers, and readers influence transcript stability, immune activation, and pathogen suppression. Growing evidence indicates that m⁶A fine-tunes the expression of defense-related genes, modulates RNA processing events, and is frequently hijacked by pathogens and pests to promote virulence. Notably, the dual role of m⁶A in enhancing plant defense and facilitating pathogen adaptation highlights its significance in the host-pathogen arms race. This review emphasizes recent advances in our understanding of m⁶A-mediated epitranscriptomic regulation in plants, with a focus on its role in responses to biotic stresses, including fungi, bacteria, virus infections, insects, and nematode attacks. This regulatory layer offers novel opportunities for crop protection through targeted manipulation of the epitranscriptomic mechanism.

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m6A mRNA甲基化在植物防御中的作用。

n6 -甲基腺苷（N6-methyladenosine, m6A）是真核生物信使RNA和非编码RNA中最丰富、最动态的RNA修饰，在转录后基因表达调控中起着关键作用。m6A写入器、擦除器和读取器的协同作用影响转录物的稳定性、免疫激活和病原体抑制。越来越多的证据表明，m6A微调防御相关基因的表达，调节RNA加工事件，并经常被病原体和害虫劫持，以促进毒力。值得注意的是，m6A在增强植物防御和促进病原体适应方面的双重作用凸显了其在宿主-病原体军备竞赛中的重要性。本文综述了植物中m6a介导的表转录组调控的最新进展，重点介绍了其在应对生物胁迫（包括真菌、细菌、病毒感染、昆虫和线虫攻击）中的作用。这一调控层通过有针对性地操纵表转录组机制为作物保护提供了新的机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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