Chromosomal 6q loss as a prognostic biomarker in Indian uveal melanoma: an OncoScan FFPE Assay study.

IF 1.8 4区医学 Q3 DERMATOLOGY

Melanoma Research Pub Date : 2026-02-01 Epub Date: 2025-11-17 DOI:10.1097/CMR.0000000000001067

Krishnakumar Subramanian, Sowmya Parameswaran, Bhavani Shankar Maradani, Vikas Khetan, Suganeswari Ganesan

引用次数: 0

Abstract

Uveal melanoma is the most common intraocular malignancy in adults. Prognostic markers such as monosomy 3 and chromosome 8q gain are well validated in Western cohorts but remain unproven in Indian patients. We retrospectively analysed 30 tumours (17 metastatic, 13 nonmetastatic) using the OncoScan FFPE Assay Kit. Loss of chromosome 6q was strongly associated with metastasis (odds ratios, 23.2; 95% confidence intervals, 2.5-214; P < 0.001), compared to monosomy 3 and 8q gain. Multivariate analysis confirmed 6q loss as the dominant independent predictor. These findings support population-specific prognostic models and highlight the clinical value of integrating 6q status into risk assessment.

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染色体6q缺失作为印度葡萄膜黑色素瘤的预后生物标志物：一项OncoScan FFPE分析研究。

葡萄膜黑色素瘤是成人最常见的眼内恶性肿瘤。3号单体和8q染色体增加等预后标志物在西方队列中得到了很好的验证，但在印度患者中尚未得到证实。我们使用OncoScan FFPE检测试剂盒回顾性分析了30例肿瘤（17例转移性，13例非转移性）。6q染色体缺失与转移密切相关(优势比为23.2；95%可信区间为2.5-214；P

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Melanoma Research 医学-皮肤病学

CiteScore

3.40

自引率

4.50%

发文量

139

审稿时长

6-12 weeks

期刊介绍： Melanoma Research is a well established international forum for the dissemination of new findings relating to melanoma. The aim of the Journal is to promote the level of informational exchange between those engaged in the field. Melanoma Research aims to encourage an informed and balanced view of experimental and clinical research and extend and stimulate communication and exchange of knowledge between investigators with differing areas of expertise. This will foster the development of translational research. The reporting of new clinical results and the effect and toxicity of new therapeutic agents and immunotherapy will be given emphasis by rapid publication of Short Communications. Thus, Melanoma Research seeks to present a coherent and up-to-date account of all aspects of investigations pertinent to melanoma. Consequently the scope of the Journal is broad, embracing the entire range of studies from fundamental and applied research in such subject areas as genetics, molecular biology, biochemistry, cell biology, photobiology, pathology, immunology, and advances in clinical oncology influencing the prevention, diagnosis and treatment of melanoma.