Revolution of Traditional Chinese Medicine in Anticancer Therapy, Applications and Future Perspective.

IF 3.3 4区医学 Q2 GENETICS & HEREDITY

Current gene therapy Pub Date : 2025-10-15 DOI:10.2174/0115665232394088250930165852

Ashima Ahuja, Sonia Singh

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引用次数: 0

Abstract

Background: The battle against cancer has gained the interest of various researchers, scientists, pharmacologists, and pharmaceutical intervenors in China. Cancer is a leading cause of death worldwide, and the exploration of Traditional Chinese medicine plays an active role in modern medicine and patients with tumors.

Method: The literature search was done in PubMed, Web of Science, Scopus, PubChem, Google Scholar, SCI, and various online data sources. The review summarizes the pharmacology and applications of TCM as an adjuvant cancer therapeutic.

Results: More than 75% of cancer cases are treated using herbal remedies and alternative therapies like TCM in China. Researchers have focused on Western medicines for inhibiting cancer cell growth, apoptosis, and metastasis, with applications of TCM medicines in cancer patients. Furthermore, the complementary and alternative therapies used for cancer patients in China are helpful for cancer-fatigue patients with a combination of chemotherapy and radiotherapy.

Discussion: TCM is a promising strategy for researchers and provides a solid foundation for formulating future hypotheses for studies on TCM-based cancer therapy with fewer side effects and improving patient health.

Conclusion: TCM anticancer progress regulates immune responses and the role of natural killer cells, T and B cells, innate immunity, macrophages, and CD4+ lymphocytes. Additionally, chemopreventive measures in TCM nanotherapeutics shed light on underlying cancer mechanisms and cancer-suppressing genes, promoting the survival of cancer-affected patients in China. Further, it provides newer insights into the therapeutic effects of traditional Chinese medicine in controlling cancer cell growth, cancer stem cells, DNA methylation, apoptosis, and improving patient compliance, promoting health.

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中医药在抗癌治疗中的革命、应用与展望

背景：在中国，与癌症的斗争已经引起了各种研究人员、科学家、药理学家和药物干预者的兴趣。癌症是世界范围内死亡的主要原因之一，中医药的探索在现代医学和肿瘤患者中发挥着积极的作用。方法：在PubMed、Web of Science、Scopus、PubChem、谷歌Scholar、SCI等网络数据库中进行文献检索。本文就中医药辅助肿瘤治疗的药理作用及应用作一综述。结果：在中国，超过75%的癌症病例使用草药和中医等替代疗法进行治疗。研究人员一直关注西药抑制癌细胞生长、凋亡和转移，以及中药在癌症患者中的应用。此外，中国癌症患者的补充和替代疗法对化疗和放疗联合治疗的癌症疲劳患者有帮助。讨论：中医药对研究人员来说是一个很有前景的策略，为未来基于中医药的癌症治疗研究提供了坚实的假设基础，这些研究的副作用更小，改善了患者的健康。结论：中药抗癌进展调节免疫应答及自然杀伤细胞、T、B细胞、先天免疫、巨噬细胞、CD4+淋巴细胞的作用。此外，中医药纳米治疗中的化学预防措施揭示了潜在的癌症机制和癌症抑制基因，促进了中国癌症患者的生存。此外，它为中医药在控制癌细胞生长，癌症干细胞，DNA甲基化，细胞凋亡，改善患者依从性，促进健康等方面的治疗作用提供了新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current gene therapy 医学-遗传学

CiteScore

6.70

自引率

2.80%

发文量

期刊介绍： Current Gene Therapy is a bi-monthly peer-reviewed journal aimed at academic and industrial scientists with an interest in major topics concerning basic research and clinical applications of gene and cell therapy of diseases. Cell therapy manuscripts can also include application in diseases when cells have been genetically modified. Current Gene Therapy publishes full-length/mini reviews and original research on the latest developments in gene transfer and gene expression analysis, vector development, cellular genetic engineering, animal models and human clinical applications of gene and cell therapy for the treatment of diseases. Current Gene Therapy publishes reviews and original research containing experimental data on gene and cell therapy. The journal also includes manuscripts on technological advances, ethical and regulatory considerations of gene and cell therapy. Reviews should provide the reader with a comprehensive assessment of any area of experimental biology applied to molecular medicine that is not only of significance within a particular field of gene therapy and cell therapy but also of interest to investigators in other fields. Authors are encouraged to provide their own assessment and vision for future advances. Reviews are also welcome on late breaking discoveries on which substantial literature has not yet been amassed. Such reviews provide a forum for sharply focused topics of recent experimental investigations in gene therapy primarily to make these results accessible to both clinical and basic researchers. Manuscripts containing experimental data should be original data, not previously published.