The effectiveness of mobile application interventions in improving medication adherence among patients with type 2 diabetes mellitus: a systematic review

IF 1 Q4 PHARMACOLOGY & PHARMACY

Journal of Pharmacy Practice and Research Pub Date : 2025-07-17 DOI:10.1002/jppr.70028

Nur Adlina Ruslan BSc, Hussam Abdeljabar Ahmad Mizher BSc, MSc, PhD, Nur Hannan Najihah Mohamad Tawpik BSc, Syahrir Zaini BSc, PhD

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Abstract

Aim

Type 2 diabetes mellitus (T2DM) is a global health concern, and medication non-adherence contributes to poor glycaemic control and complications. Mobile applications are a potential strategy to improve adherence, but their effectiveness remains uncertain. This systematic review evaluates the effectiveness of mobile applications interventions in improving medication adherence in patients with T2DM.

Data Sources

A comprehensive search of PubMed, Cochrane Library, and Scopus was conducted.

Study Selection

Studies included were English-language studies published in from 2013–2023. Study quality was assessed using the Mixed Method Appraisal Tool.

Results

Seven clinical studies with 717 participants (median age 54.7 years) were included. All studies showed improvements in adherence, but only four reported statistically significant changes. Among these, three studies also showed significant reductions in haemoglobin A1c (HbA1c) levels, suggesting a positive clinical impact. The studies were generally of high quality.

Conclusion

Mobile applications appear to improve medication adherence in T2DM patients compared to traditional care. However, the specific application features that enhance adherence are unclear due to variations in study designs and small sample sizes. Future research should focus on identifying key applications characteristics, improving usability, and ensuring cost-effectiveness to optimize patient outcomes.

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手机应用干预改善2型糖尿病患者服药依从性的有效性：一项系统综述

目的2型糖尿病（T2DM）是一个全球性的健康问题，药物依从性差会导致血糖控制不良和并发症。移动应用程序是提高依从性的潜在策略，但其有效性仍不确定。本系统综述评估了移动应用程序干预在改善T2DM患者服药依从性方面的有效性。数据来源综合检索PubMed、Cochrane Library、Scopus。研究选择纳入的研究是2013-2023年发表的英语研究。采用混合方法评价工具评价研究质量。结果纳入7项临床研究，717名参与者（中位年龄54.7岁）。所有的研究都显示了依从性的改善，但只有四项报告了统计学上显著的变化。其中，三项研究也显示血红蛋白A1c （HbA1c）水平显著降低，提示积极的临床影响。这些研究一般都是高质量的。结论与传统护理相比，移动应用程序可提高T2DM患者的药物依从性。然而，由于研究设计的差异和小样本量，增强依从性的具体应用功能尚不清楚。未来的研究应侧重于确定关键应用的特征，提高可用性，并确保成本效益，以优化患者的结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Pharmacy Practice and Research Health Professions-Pharmacy

CiteScore

1.60

自引率

9.50%

发文量

期刊介绍： The purpose of this document is to describe the structure, function and operations of the Journal of Pharmacy Practice and Research, the official journal of the Society of Hospital Pharmacists of Australia (SHPA). It is owned, published by and copyrighted to SHPA. However, the Journal is to some extent unique within SHPA in that it ‘…has complete editorial freedom in terms of content and is not under the direction of the Society or its Council in such matters…’. This statement, originally based on a Role Statement for the Editor-in-Chief 1993, is also based on the definition of ‘editorial independence’ from the World Association of Medical Editors and adopted by the International Committee of Medical Journal Editors.