Alkyne-tagged ribitol-5-phosphate derivatives for metabolic labelling of alpha-dystroglycan.

Abstract

The glycoprotein α-dystroglycan is essential in establishing cell-matrix interactions and is implicated in the pathology of muscular dystrophies. Novel tools are needed to study its rare and intriguing O-mannosyl glycans. This report describes the synthesis and evaluation of alkyne-tagged ribitol-5-phosphate derivatives for the metabolic labelling of α-dystroglycan in mammalian cells.