Optimal obesity and lipid-related predictors of diabetes mellitus in middle-aged and elderly patients with liver disease in China: a CHARLS cross-sectional study.

IF 1.2 Q4 ENDOCRINOLOGY & METABOLISM

Diabetology International Pub Date : 2025-09-18 eCollection Date: 2025-10-01 DOI:10.1007/s13340-025-00851-9

Yang Wu, Tian Li, Yanan Zhang, Chujiang Wu, Xiaofeng Zheng, Jiucong Zhang, Bing Liang

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引用次数: 0

Abstract

Introduction: Chinese middle-aged and elderly (≥45 years old) liver disease patients have a high diabetes mellitus (DM) incidence with gender differences. Identify the optimal obesity and blood lipid-related predictors of DM in such patients by sex.

Methods: Using China Health and Retirement Longitudinal Study (CHARLS) 2011-2020 data, we explored DM predictors by sex, evaluating with receiver operating characteristic (ROC), area under curve (AUC), etc., to calculate odds ratio (OR) and 95% confidence interval (CI) after confounder adjustment.

Results: Many indexes were significant (P < 0.05). Obesity and lipid-related indexes had certain discrimination (AUC > 0.5), with the triglyceride-glucose (TyG) index performing best (AUC = 0.78). The visceral adiposity index (VAI) (OR = 1.08, 95%CI = 1.04-1.12) and the triglyceride-glucose-body mass index (TyG-BMI) (OR = 1.14, 95%CI = 1.06-1.22) promoted DM in male patients, while VAI (OR = 1.12, 95%CI = 1.08-1.16) and the triglyceride-glucose-waist circumference (TyG-WC) (OR = 1.15, 95%CI = 1.09-1.21) did so in female patients.

Conclusion: TyG-BMI and TyG-WC are the best DM predictors for male and female liver disease patients, respectively. VAI also has predictive value for DM prevention.

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中国中老年肝病患者糖尿病的最佳肥胖和脂质相关预测因素：CHARLS横断面研究

中国中老年（≥45岁）肝病患者糖尿病（DM）发病率较高，且存在性别差异。按性别确定糖尿病患者的最佳肥胖和血脂相关预测因素。方法：利用中国健康与退休纵向研究（CHARLS） 2011-2020年数据，通过性别、受试者工作特征（ROC）、曲线下面积（AUC）等指标探讨糖尿病的预测因素，计算混杂校正后的比值比（OR）和95%置信区间（CI）。结果：多项指标均有显著性差异（p0.5），其中甘油三酯-葡萄糖（TyG）指标表现最佳（AUC = 0.78）。内脏脂肪指数（VAI）（OR = 1.08, 95%CI = 1.04-1.12）和甘油三酯-葡萄糖-体重指数（TyG-BMI）（OR = 1.14, 95%CI = 1.06-1.22）在男性患者中促进DM，而VAI （OR = 1.12, 95%CI = 1.08-1.16）和甘油三酯-葡萄糖-腰围（TyG-WC）（OR = 1.15, 95%CI = 1.09-1.21）在女性患者中促进DM。结论：TyG-BMI和TyG-WC分别是男性和女性肝病患者DM的最佳预测指标。VAI对糖尿病的预防也有预测价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetology International ENDOCRINOLOGY & METABOLISM-

CiteScore

3.90

自引率

4.50%

发文量

期刊介绍： Diabetology International, the official journal of the Japan Diabetes Society, publishes original research articles about experimental research and clinical studies in diabetes and related areas. The journal also presents editorials, reviews, commentaries, reports of expert committees, and case reports on any aspect of diabetes. Diabetology International welcomes submissions from researchers, clinicians, and health professionals throughout the world who are interested in research, treatment, and care of patients with diabetes. All manuscripts are peer-reviewed to assure that high-quality information in the field of diabetes is made available to readers. Manuscripts are reviewed with due respect for the author''s confidentiality. At the same time, reviewers also have rights to confidentiality, which are respected by the editors. The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.