Impact of isCGM on quality of life in overweight individuals with impaired glucose tolerance or mild diabetes: secondary analysis of a pilot randomized controlled study.

IF 1.1 Q4 ENDOCRINOLOGY & METABOLISM

Diabetology International Pub Date : 2025-07-23 eCollection Date: 2025-10-01 DOI:10.1007/s13340-025-00838-6

Seiji Nishikage, Yushi Hirota, Yasushi Nakagawa, Mei Nakatsuji, Shuichiro Saito, Kai Yoshimura, Mariko Ueda, Akane Yamamoto, Tomofumi Takayoshi, Atsuko Matsuoka, Michiko Takahashi, Akihiko Takeda, Kazuki Yokota, Tomoaki Nakamura, Kazuhiko Sakaguchi, Wataru Ogawa

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引用次数: 0

Abstract

Background: The impact of intermittently scanned continuous glucose monitoring (isCGM) on quality of life (QoL) for overweight individuals with impaired glucose tolerance (IGT) or mild type 2 diabetes (HbA1c ≤ 7.0%) remains unclear.

Methods: In this secondary analysis of our pilot weight-loss RCT, 40 overweight individuals (BMI, ≥ 25 kg/m²) were randomized to isCGM (isCGM plus diet-and-exercise therapy) or control (diet-and-exercise therapy alone) groups. QoL was assessed with the SF-36 questionnaire over a 6-month intervention.

Results: After exclusion of participants with missing data or who withdrew consent, 17 individuals in the isCGM group (median [interquartile range] age, 51.0 [47.0-62.5] years; BMI, 35.0 [32.2-39.0] kg/m²) and 16 individuals in the control group (age, 51.0 [41.8-65.0] years; BMI, 29.4 [25.3-35.8] kg/m²) were analyzed. No significant differences in QoL changes over the intervention period were observed between the two groups. Within the isCGM group, the Mental Component Summary (MCS) score improved significantly (from 44.8 to 48.4, P < 0.05), whereas the Role/Social Component Summary score declined significantly (from 52.2 to 44.8, P < 0.05). Scan frequency correlated positively with baseline Vitality, Mental Health, and MCS scores. Changes in time above range and standard deviation for sensor glucose were negatively correlated with changes in the General Health score.

Conclusion: isCGM did not improve QoL scores relative to the control group for overweight individuals with IGT or mild diabetes. Within-group analysis suggested that isCGM improved mental QoL but lowered perceived social QoL. Tailored support addressing psychological and social needs may maximise isCGM benefits.

Supplementary information: The online version contains supplementary material available at 10.1007/s13340-025-00838-6.

查看原文本刊更多论文

isCGM对伴有糖耐量受损或轻度糖尿病的超重个体生活质量的影响：一项先导随机对照研究的二次分析

背景：间歇性扫描连续血糖监测（isCGM）对超重伴有糖耐量受损（IGT）或轻度2型糖尿病（HbA1c≤7.0%）患者生活质量（QoL）的影响尚不清楚。方法：在我们的试点减肥RCT的二级分析中，40名超重个体（BMI≥25 kg/m2）被随机分为isCGM （isCGM加饮食运动治疗）组或对照组（单独饮食运动治疗）组。在6个月的干预期间，使用SF-36问卷评估生活质量。结果：在排除资料缺失或撤回同意的参与者后，分析了isCGM组17例（年龄中位数[四分位数间距]51.0[47.0-62.5]岁，BMI为35.0 [32.2-39.0]kg/m2）和对照组16例（年龄51.0[41.8-65.0]岁，BMI为29.4 [25.3-35.8]kg/m2）。干预期间，两组患者的生活质量变化无显著差异。在isCGM组中，心理成分总结（MCS）评分显著提高（从44.8提高到48.4）。结论：对于超重的IGT或轻度糖尿病患者，isCGM没有改善相对于对照组的生活质量评分。组内分析表明，isCGM改善了心理生活质量，但降低了感知社会生活质量。针对心理和社会需求的量身定制的支持可以最大限度地提高isCGM的效益。补充信息：在线版本包含补充资料，下载地址：10.1007/s13340-025-00838-6。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetology International ENDOCRINOLOGY & METABOLISM-

CiteScore

3.90

自引率

4.50%

发文量

期刊介绍： Diabetology International, the official journal of the Japan Diabetes Society, publishes original research articles about experimental research and clinical studies in diabetes and related areas. The journal also presents editorials, reviews, commentaries, reports of expert committees, and case reports on any aspect of diabetes. Diabetology International welcomes submissions from researchers, clinicians, and health professionals throughout the world who are interested in research, treatment, and care of patients with diabetes. All manuscripts are peer-reviewed to assure that high-quality information in the field of diabetes is made available to readers. Manuscripts are reviewed with due respect for the author''s confidentiality. At the same time, reviewers also have rights to confidentiality, which are respected by the editors. The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.