Development and optimization of an integrated exercise and nutrition program for ovarian cancer patients: Phase I of the BENITA multi-center study

IF 4.1 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Gynecologic oncology Pub Date : 2025-10-17 DOI:10.1016/j.ygyno.2025.10.005

Tabea Maurer , Matthias H. Belau , Birgit-Christiane Zyriax , Götz Welsch , Bettina Jagemann , Jenny Chang-Claude , Anne Daubmann , Anika Buchholz , Alexander Fierenz , Karin Glismann , Annika Moeller , Jalid Sehouli , Hannah Woopen , Pauline Wimberger , Philipp Harter , Sabrina Kaiser , Nicolai Maass , Marion Kiechle , Tobias Engler , Barbara Schmalfeldt , Holger Schulz

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引用次数: 0

Abstract

Background

Ovarian cancer patients face treatment-related challenges such as malnutrition and muscle wasting associated with cancer cachexia. If left untreated, these complications can severely impact quality of life and autonomy. The BENITA study aims to develop and evaluate a tailored exercise and nutrition program during and after first-line chemotherapy. Phase I focused on program development and optimization; Phase II will test its effectiveness in a randomized controlled trial.

Methods

Semi-structured interviews were conducted with patients, survivors, physicians, nutrition and physiotherapy experts, and a health insurance representative. Thematic analysis following Braun and Clarke was used to identify key insights for program design and implementation.

Results

Patients' motivation to engage in exercise and nutrition was driven by enjoyment and external encouragement. Barriers included chemotherapy-induced fatigue, physical weakness, and psychological strain. Uncertainty about safe training post-surgery was common. Regular support from healthcare professionals was seen as essential for confidence and adherence.

Discussion

Findings highlight the need for a personalized, flexible program tailored to ovarian cancer patients' needs. A blended digital approach combining self-guided elements with professional support could improve implementation, offering customized exercise routines, nutrition plans, and regular check-ins to facilitate patient-centered participation.

查看原文本刊更多论文

开发和优化卵巢癌患者的综合运动和营养计划：BENITA多中心研究的I期。

背景：卵巢癌患者面临着治疗相关的挑战，如与癌症恶病质相关的营养不良和肌肉萎缩。如果不及时治疗，这些并发症会严重影响生活质量和自主性。BENITA研究旨在开发和评估一线化疗期间和之后的量身定制的运动和营养计划。第一阶段侧重于项目开发和优化；第二阶段将在随机对照试验中测试其有效性。方法：对患者、幸存者、医生、营养和物理治疗专家以及一名健康保险代表进行半结构化访谈。遵循Braun和Clarke的主题分析被用于识别程序设计和执行的关键见解。结果：患者参与运动和营养的动机是由享受和外部鼓励驱动的。障碍包括化疗引起的疲劳、身体虚弱和心理紧张。术后安全训练的不确定性很常见。医疗保健专业人员的定期支持被视为信心和坚持的必要条件。讨论：研究结果强调需要一个个性化的，灵活的方案量身定制卵巢癌患者的需要。将自我指导元素与专业支持相结合的混合数字方法可以改善实施，提供定制的锻炼程序、营养计划和定期检查，以促进以患者为中心的参与。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gynecologic oncology 医学-妇产科学

CiteScore

8.60

自引率

6.40%

发文量

1062

审稿时长

37 days

期刊介绍： Gynecologic Oncology, an international journal, is devoted to the publication of clinical and investigative articles that concern tumors of the female reproductive tract. Investigations relating to the etiology, diagnosis, and treatment of female cancers, as well as research from any of the disciplines related to this field of interest, are published. Research Areas Include: • Cell and molecular biology • Chemotherapy • Cytology • Endocrinology • Epidemiology • Genetics • Gynecologic surgery • Immunology • Pathology • Radiotherapy