The Use of Ionic Liquids and Deep Eutectic Solvents in the Extraction of Phytochemicals with Bioactive Properties: A Review

IF 3.2 4区 农林科学 Q2 FOOD SCIENCE & TECHNOLOGY
Erlane da Rocha Fernandes, Jefferson Henrique Tiago Barros, Patrícia Martins Guarda, Emerson Adriano Guarda
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引用次数: 0

Abstract

Innovative solvents like Ionic Liquids (ILs), Deep Eutectic Solvents (DES), and more recently, Natural Deep Eutectic Solvents (NaDES) have emerged as promising alternatives to conventional organic solvents for the extraction of bioactive compounds from plants. These solvents have gained attention due to their efficiency, lower environmental impact, and potential to enhance the selectivity of target compound extraction. Despite significant advancements in this field, a literature review revealed a lack of systematic reviews on the application of these solvents in plant bioactive extraction, over the past five years. Therefore, this study aims to compare ILs, DES, and NaDES in terms of efficiency, applicability, usability, and environmental impact, providing a comprehensive overview of the trends and challenges in this emerging field. The PRISMA methodology was used for article selection, resulting in a total of 77 studies analyzed. The findings indicate a growing number of studies on the use of DES and NaDES, whereas research on ILs for this purpose remains relatively scarce within the investigated period. Furthermore, an increasing trend in combined extraction methods was observed, with a particular emphasis on ultrasound-assisted extraction (UAE) and microwave-assisted extraction (MAE), which have shown promising effects when used alongside these solvents to enhance bioactive compound extraction. This review contributes to a deeper understanding of the emerging role of DES and NaDES in plant bioactive extraction and highlights the need for further investigations on ILs, particularly within the context of sustainable and cost-effective extraction methodologies.

Graphical Abstract

Abstract Image

离子液体和深共晶溶剂在提取具有生物活性的植物化学物质中的应用综述
离子液体(ILs)、深共晶溶剂(DES)以及最近的天然深共晶溶剂(NaDES)等创新溶剂已经成为传统有机溶剂提取植物生物活性化合物的有希望的替代品。这些溶剂因其高效、低环境影响和提高目标化合物萃取选择性的潜力而受到关注。尽管这一领域取得了重大进展,但在过去的五年中,文献综述显示这些溶剂在植物生物活性提取中的应用缺乏系统的综述。因此,本研究旨在比较ILs、DES和NaDES在效率、适用性、可用性和环境影响方面的差异,全面概述这一新兴领域的发展趋势和挑战。采用PRISMA方法进行文章选择,共分析了77项研究。研究结果表明,关于DES和NaDES使用的研究越来越多,而在调查期间,用于此目的的il研究仍然相对较少。此外,观察到联合提取方法的增长趋势,特别是超声辅助提取(UAE)和微波辅助提取(MAE),当与这些溶剂一起使用时,它们显示出有希望的效果,以增强生物活性化合物的提取。这一综述有助于加深对DES和NaDES在植物生物活性提取中的新兴作用的理解,并强调了进一步研究il的必要性,特别是在可持续和具有成本效益的提取方法的背景下。图形抽象
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来源期刊
Food Biophysics
Food Biophysics 工程技术-食品科技
CiteScore
5.80
自引率
3.30%
发文量
58
审稿时长
1 months
期刊介绍: Biophysical studies of foods and agricultural products involve research at the interface of chemistry, biology, and engineering, as well as the new interdisciplinary areas of materials science and nanotechnology. Such studies include but are certainly not limited to research in the following areas: the structure of food molecules, biopolymers, and biomaterials on the molecular, microscopic, and mesoscopic scales; the molecular basis of structure generation and maintenance in specific foods, feeds, food processing operations, and agricultural products; the mechanisms of microbial growth, death and antimicrobial action; structure/function relationships in food and agricultural biopolymers; novel biophysical techniques (spectroscopic, microscopic, thermal, rheological, etc.) for structural and dynamical characterization of food and agricultural materials and products; the properties of amorphous biomaterials and their influence on chemical reaction rate, microbial growth, or sensory properties; and molecular mechanisms of taste and smell. A hallmark of such research is a dependence on various methods of instrumental analysis that provide information on the molecular level, on various physical and chemical theories used to understand the interrelations among biological molecules, and an attempt to relate macroscopic chemical and physical properties and biological functions to the molecular structure and microscopic organization of the biological material.
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