Exposure and disease burden of fumonisins and aflatoxins from sorghum consumption in Ethiopia.

IF 3.5 4区医学 Q1 MEDICINE, LEGAL

Regulatory Toxicology and Pharmacology Pub Date : 2025-10-14 DOI:10.1016/j.yrtph.2025.105966

J A Sadik, N Fentahun, I D Brouwer, M Tessema, H J van der Fels-Klerx

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引用次数: 0

Abstract

Studies on mycotoxin exposure from sorghum consumption and related public health risk estimation are rarely available in Ethiopia. The aim of this research was to assess fumonisin and aflatoxin exposure of adults through sorghum consumption in the Amhara National Regional State (ANRS) and at national level in Ethiopia and to estimate related health risks. Data on fumonisin and aflatoxin concentrations in sorghum samples were collected from a survey and literature. Estimated fumonisin exposure in the ANRS and at national level were below the FAO/WHO limit of 2000 ng/kg bw day to be considered a health concern. The estimated aflatoxin exposure levels in the ANRS and at national level fall below the Margin of Exposure value of 10000, indicating potential health concern. The incidence of hepatocellular carcinoma due to aflatoxin exposure in the ANRS ranges from 0.0003 to 0.017 while at national level, it ranges from 0.181 to 8.47 (per100.000 persons/year). The related disability-adjusted life years estimates for the ANRS and at national level ranged from 0.0003 to 0.019 and 0.204 to 11.230, respectively. Aflatoxin exposures were driven more by sorghum intake than aflatoxin contamination. Dietary intervention could further reduce the health risk estimates.

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埃塞俄比亚食用高粱中伏马菌素和黄曲霉毒素的暴露和疾病负担。

在埃塞俄比亚，很少有关于食用高粱引起的霉菌毒素暴露和相关公共卫生风险评估的研究。本研究的目的是评估阿姆哈拉民族地区州（ANRS）和埃塞俄比亚国家一级成年人通过食用高粱接触伏马菌素和黄曲霉毒素的情况，并估计相关的健康风险。高粱样品中伏马菌素和黄曲霉毒素浓度的数据从调查和文献中收集。在ANRS和国家一级估计的伏马菌素暴露量低于粮农组织/世卫组织每天2000纳克/公斤体重被视为健康问题的限值。在ANRS和国家一级估计的黄曲霉毒素暴露水平低于10000的暴露限度值，表明潜在的健康问题。在ANRS中，黄曲霉毒素暴露导致的肝细胞癌发病率为0.0003至0.017，而在全国水平上，这一发病率为0.181至8.47（每10万人/年）。ANRS和国家水平的相关残疾调整寿命年估计值分别在0.0003至0.019和0.204至11.230之间。与黄曲霉毒素污染相比，高粱摄入量更能驱动黄曲霉毒素暴露。饮食干预可以进一步降低健康风险估计。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Regulatory Toxicology and Pharmacology 医学-毒理学

CiteScore

6.70

自引率

8.80%

发文量

147

审稿时长

58 days

期刊介绍： Regulatory Toxicology and Pharmacology publishes peer reviewed articles that involve the generation, evaluation, and interpretation of experimental animal and human data that are of direct importance and relevance for regulatory authorities with respect to toxicological and pharmacological regulations in society. All peer-reviewed articles that are published should be devoted to improve the protection of human health and environment. Reviews and discussions are welcomed that address legal and/or regulatory decisions with respect to risk assessment and management of toxicological and pharmacological compounds on a scientific basis. It addresses an international readership of scientists, risk assessors and managers, and other professionals active in the field of human and environmental health. Types of peer-reviewed articles published: -Original research articles of relevance for regulatory aspects covering aspects including, but not limited to: 1.Factors influencing human sensitivity 2.Exposure science related to risk assessment 3.Alternative toxicological test methods 4.Frameworks for evaluation and integration of data in regulatory evaluations 5.Harmonization across regulatory agencies 6.Read-across methods and evaluations -Contemporary Reviews on policy related Research issues -Letters to the Editor -Guest Editorials (by Invitation)