Three-Component Copper-Catalyzed 1,4-Carboamination of 1,3-Dienes

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-10-17 DOI:10.1021/acs.orglett.5c03922

Siyuan Shi, Zonglei Guo, Yanyan Li, Chengdong Wang, Hui Wang

引用次数: 0

Abstract

We herein report a highly selective copper-catalyzed three-component 1,4-carboamination of 1,3-dienes with activated alkyl bromides and amines, providing a general and practical route to functionalized allylamine derivatives. This operationally simple protocol demonstrates a broad substrate scope (>45 examples), good functional group tolerance, and high E/Z ratio selectivity. The synthetic utility of this method was further exemplified by its successful application in the late-stage functionalization of various bioactive molecules.

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三组分铜催化1,3-二烯的1,4-碳胺化反应

我们在此报道了一种高选择性铜催化1,3-二烯与活化的烷基溴和胺的三组分1,4-碳胺化反应，为功能化烯丙胺衍生物提供了一种通用和实用的途径。该操作简单的协议显示了广泛的底物范围（>；45个例子），良好的官能团耐受性和高E/Z比选择性。该方法成功应用于各种生物活性分子的后期功能化，进一步证明了该方法的合成实用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.