Molecular Mechanisms of Respiratory Syncytial Virus Pathogenesis.

IF 34.5 1区医学 Q1 PATHOLOGY

Annual Review of Pathology-Mechanisms of Disease Pub Date : 2025-10-16 DOI:10.1146/annurev-pathmechdis-042424-114052

Madison J Granoski,Aleksandra Stojic,Stephen Z Lee,David J Marchant

引用次数: 0

Abstract

Respiratory syncytial virus (RSV) is one of the leading causes of infant hospitalization and mortality worldwide. RSV pathogenesis is a result of various virus-host interactions. While significant work has been done to elucidate mechanisms of RSV pathogenesis at a systemic level from the host perspective, here we examine how RSV pathogenesis occurs on a molecular level. While each RSV protein plays an essential role in establishing and advancing disease, each one also executes multifaceted strategies for evasion of host detection. In this review, we outline how each component of the RSV replication cycle works to co-opt host cell proteins and modulate host immune responses during entry, transcription, replication, translation, assembly, and egress. We examine the latest literature regarding RSV protein function and discuss outstanding questions in the field.

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呼吸道合胞病毒发病机制的分子机制。

呼吸道合胞病毒（RSV）是全球婴儿住院和死亡的主要原因之一。RSV发病机制是多种病毒与宿主相互作用的结果。虽然已经做了大量的工作来阐明从宿主角度在系统水平上的RSV发病机制，但在这里，我们研究RSV发病机制是如何在分子水平上发生的。虽然每一种RSV蛋白在疾病的建立和发展中都发挥着重要作用，但每一种RSV蛋白也都执行着逃避宿主检测的多方面策略。在这篇综述中，我们概述了RSV复制周期的每个组成部分如何在进入、转录、复制、翻译、组装和输出过程中协同宿主细胞蛋白并调节宿主免疫反应。我们研究了关于RSV蛋白功能的最新文献，并讨论了该领域的突出问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annual Review of Pathology-Mechanisms of Disease 医学-病理学

CiteScore

62.60

自引率

0.00%

发文量

期刊介绍： The Annual Review of Pathology: Mechanisms of Disease is a scholarly journal that has been published since 2006. Its primary focus is to provide a comprehensive overview of recent advancements in our knowledge of the causes and development of significant human diseases. The journal places particular emphasis on exploring the current and evolving concepts of disease pathogenesis, as well as the molecular genetic and morphological changes associated with various diseases. Additionally, the journal addresses the clinical significance of these findings. In order to increase accessibility and promote the broad dissemination of research, the current volume of the journal has transitioned from a gated subscription model to an open access format. This change has been made possible through the Annual Reviews' Subscribe to Open program, which allows all articles published in this volume to be freely accessible to readers. As part of this transition, all articles in the journal are published under a Creative Commons Attribution (CC BY) license, which encourages open sharing and use of the research.