Clinicopathological implications of miR-3127 in melanoma.

IF 3 Q3 PATHOLOGY

Journal of Pathology and Translational Medicine Pub Date : 2025-10-16 DOI:10.4132/jptm.2025.07.08

Truong Phan-Xuan Nguyen, Minh-Khang Le, Chau M Bui, Vuong Gia Huy

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引用次数: 0

Abstract

Background: Cutaneous melanoma is the most lethal of all skin cancers. Recent studies suggested that miR-3127 is dysregulated in multiple tumor types and has important roles in tumorigenesis and cancer progression, giving it potential as a prognostic biomarker. The aim of this study was to use bioinformatic analysis to assess miR-3127 expression and correlate expression patterns with disease course in patients with cutaneous melanoma.

Methods: miRNA, mRNA sequencing, DNA methylation data, and clinical information of cutaneous melanoma cases were downloaded from the Human Cancer Atlas - Skin Cutaneous Melanoma (TCGA-SKCM). miR-3127 expression was classified into miR-3127-low and miR-3127-high clusters using maximally selected rank statistics.

Results: Clustering analysis showed that high expression of miR-3127 (≥20.3 reads per million) was associated with worse progression-free (p < .001) and overall (p = .011) survival compared to low miR-3127 expression. More than five thousand differentially expressed genes between the two miR-3127 sample groups encoded cell differentiation markers, cytokines, growth factors, translocated cancer genes, and oncogenes. Pathway analysis revealed that miR-3127-high samples related to activity of proliferation, DNA repair, and ultraviolet response.

Conclusions: The expression level of miR-3127 could act as a prognostic indicator for patients with melanoma.

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miR-3127在黑色素瘤中的临床病理意义。

背景：皮肤黑色素瘤是所有皮肤癌中最致命的。最近的研究表明，miR-3127在多种肿瘤类型中失调，并在肿瘤发生和癌症进展中发挥重要作用，使其具有作为预后生物标志物的潜力。本研究的目的是利用生物信息学分析来评估miR-3127的表达，并将表达模式与皮肤黑色素瘤患者的病程联系起来。方法：从人类癌症图谱-皮肤黑色素瘤（TCGA-SKCM）中下载皮肤黑色素瘤病例的miRNA、mRNA测序、DNA甲基化数据和临床信息。使用最大选择的秩统计将miR-3127的表达分为miR-3127-low和miR-3127-high两个簇。结果：聚类分析显示，与低表达miR-3127相比，高表达miR-3127（≥20.3 reads / million）与更差的无进展生存（p < 0.001）和总体生存（p = 0.011）相关。在两个miR-3127样本组之间，有超过5000个差异表达基因编码细胞分化标记物、细胞因子、生长因子、易位癌基因和致癌基因。通路分析显示miR-3127-high样本与增殖活性、DNA修复和紫外线反应有关。结论：miR-3127的表达水平可作为黑色素瘤患者的预后指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Pathology and Translational Medicine PATHOLOGY-

CiteScore

5.00

自引率

4.20%

发文量

审稿时长

14 weeks

期刊介绍： The Journal of Pathology and Translational Medicine is an open venue for the rapid publication of major achievements in various fields of pathology, cytopathology, and biomedical and translational research. The Journal aims to share new insights into the molecular and cellular mechanisms of human diseases and to report major advances in both experimental and clinical medicine, with a particular emphasis on translational research. The investigations of human cells and tissues using high-dimensional biology techniques such as genomics and proteomics will be given a high priority. Articles on stem cell biology are also welcome. The categories of manuscript include original articles, review and perspective articles, case studies, brief case reports, and letters to the editor.