Exploring the Current Tools in Cardiovascular Risk Assessment in the Middle East and the Need for Region-Specific Models - A Scoping Review.

IF 2.8 3区医学 Q1 Pharmacology, Toxicology and Pharmaceutics

Therapeutics and Clinical Risk Management Pub Date : 2025-10-10 eCollection Date: 2025-01-01 DOI:10.2147/TCRM.S520628

Gamilah Abdulkarem Al-Ezzi, Adliah Mhd Ali, Mohammed Abdullah Kubas, Adyani Md Redzuan

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Abstract

Background: Cardiovascular diseases (CVDs) are a major contributor to premature mortality, disability, and reduced quality of life globally. Assessing CVD risks is central to primary prevention, prompting the development of numerous tools to predict CVD risks for the general population. However, it is unclear which tools are recommended in clinical practice in the Middle East region.

Aim: This scoping review aims to identify, review, and summarize the available literature on CVD risk assessment tools recommended for the general population in the Middle East region.

Methods: The scoping review synthesized the literature on CVD risk assessment tools recommended for the general population in the Middle East region. It followed PRISMA-ScR guidelines, covering searches in the Web of Science (WOS), Medline, and Scopus databases. English-language articles published between 2015 and 2024 that focused on the primary prevention of CVDs in sixteen Middle Eastern countries were included.

Results: Seventeen articles met the inclusion criteria. The studies were distributed over Cyprus (n=1), Iran (n=7), Saudi Arabia (n=4), Qatar (n=1), the United Arab Emirates (n=3), and Egypt (n=1). Various tools are recommended in these countries, including validated Western tools such as ACC/AHA Pooled-Cohort Equations (PCE), Systematic Coronary Risk Evaluation 2 (SCORE 2), World Health Organization charts (WHO/ ISH) for the Eastern Mediterranean region (EMR), Cardiovascular Disease Risk Algorithm (QRISK3), and PREDICT. Some studies in Iran, Saudi Arabia, the United Arab Emirates, and Egypt focused on developing new CVD risk tools tailored for national use.

Conclusion: Current studies on CVD risk assessment are limited and have been conducted in six Middle Eastern countries. These studies recommend various tools, including both validated Western models and locally developed frameworks. However, the limitations of existing tools and the gaps in current research underscore the need for further studies to develop or recalibrate models that account for country-specific CVD risk factors across the region.

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探索中东心血管风险评估的现有工具和对区域特定模型的需求-范围综述

背景：心血管疾病（cvd）是全球过早死亡、残疾和生活质量下降的主要原因。评估心血管疾病风险是一级预防的核心，这促使开发了许多工具来预测普通人群的心血管疾病风险。然而，目前尚不清楚哪些工具在中东地区的临床实践中被推荐。目的：本综述旨在识别、回顾和总结中东地区推荐的心血管疾病风险评估工具的现有文献。方法：对中东地区一般人群推荐的心血管疾病风险评估工具的文献进行范围综述。它遵循PRISMA-ScR指南，涵盖了Web of Science （WOS）、Medline和Scopus数据库中的搜索。纳入了2015年至2024年间发表的英语文章，重点关注16个中东国家心血管疾病的初级预防。结果：17篇文章符合纳入标准。这些研究分布在塞浦路斯（n=1）、伊朗（n=7）、沙特阿拉伯（n=4）、卡塔尔（n=1）、阿拉伯联合酋长国（n=3）和埃及（n=1）。这些国家推荐使用各种工具，包括经过验证的西方工具，如ACC/AHA合并队列方程（PCE）、系统性冠状动脉风险评估2 （SCORE 2）、世界卫生组织东地中海地区（EMR）图表（WHO/ ISH）、心血管疾病风险算法（QRISK3）和PREDICT。在伊朗、沙特阿拉伯、阿拉伯联合酋长国和埃及进行的一些研究侧重于开发适合本国使用的新的心血管疾病风险工具。结论：目前关于心血管疾病风险评估的研究有限，仅在六个中东国家进行。这些研究推荐了各种工具，包括经过验证的西方模型和当地开发的框架。然而，现有工具的局限性和当前研究中的差距突出表明需要进一步研究，以开发或重新校准模型，以考虑整个区域特定国家的心血管疾病风险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Therapeutics and Clinical Risk Management HEALTH CARE SCIENCES & SERVICES-

CiteScore

5.30

自引率

3.60%

发文量

139

审稿时长

16 weeks

期刊介绍： Therapeutics and Clinical Risk Management is an international, peer-reviewed journal of clinical therapeutics and risk management, focusing on concise rapid reporting of clinical studies in all therapeutic areas, outcomes, safety, and programs for the effective, safe, and sustained use of medicines, therapeutic and surgical interventions in all clinical areas. The journal welcomes submissions covering original research, clinical and epidemiological studies, reviews, guidelines, expert opinion and commentary. The journal will consider case reports but only if they make a valuable and original contribution to the literature. As of 18th March 2019, Therapeutics and Clinical Risk Management will no longer consider meta-analyses for publication. The journal does not accept study protocols, animal-based or cell line-based studies.