A Review of Mechanistic Effects of Low-Intensity Focused Ultrasound.

IF 3.5 3区医学 Q2 CLINICAL NEUROLOGY

Neuromodulation Pub Date : 2025-10-16 DOI:10.1016/j.neurom.2025.07.006

Pravarakhya Puppalla, Ugur Kilic, Derek D George, AnneLeigh Twer, Minza Haque, Lotanna Ojukwu, Julie G Pilitsis

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引用次数: 0

Abstract

Background/objectives: Low-intensity focused ultrasound (LIFU) has become increasingly used in neuromodulation. However, its mechanisms of action are less well understood. Here, we provide a scoping review of the effects of LIFU on nervous system tissue.

Materials and methods: We evaluated the PubMed, SCOPUS, and Web of Science data bases for articles using the keywords related to LIFU and neuromodulation; 3970 articles were retrieved and titles screened by two authors (AT and MH) with conflicts resolved by one author (PP). The abstract review included 837 articles, and full-text review included 371 articles; 157 articles were included in the final manuscript.

Results: The mechanisms of action of LIFU for neuromodulation have been studied in vitro, in preclinical models, and in humans. LIFU exerts both excitatory and inhibitory modulatory effects through ion channel activation, changes in neurotransmission, and certain gene expression pathways. These changes cause localized and distributed effects in brain tissue and in behavioral modification in human trials and nonhuman models, depending on stimulation parameters and region targeted. Most LIFU research focuses on cerebral neuromodulation whereas some data exist for spinal cord and peripheral nerve neuromodulation.

Conclusion: Considerable growth in research evaluating LIFU's ability to modulate the nervous system has occurred. Although safety and efficacy have been indicated, heterogeneity in LIFU operating parameters may cause nuanced differential effects on target tissue. By further elucidating the mechanisms of LIFU neuromodulation, future research will advance treatments for chronic neurologic diseases.

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低强度聚焦超声的机理研究进展。

背景/目的：低强度聚焦超声（LIFU）在神经调节中的应用越来越广泛。然而，其作用机制尚不清楚。在此，我们对LIFU对神经系统组织的影响进行了综述。材料和方法：我们对PubMed、SCOPUS和Web of Science数据库中使用LIFU和神经调节相关关键词的文章进行了评估；共检索到3970篇文章，标题由两位作者（AT和MH）筛选，冲突由一位作者（PP）解决。摘要综述纳入837篇，全文综述纳入371篇；定稿中收录了157篇文章。结果：在体外、临床前模型和人体中研究了LIFU对神经调节的作用机制。LIFU通过激活离子通道、改变神经传递和某些基因表达途径发挥兴奋性和抑制性调节作用。在人体试验和非人体模型中，这些变化在脑组织和行为改变中引起局部和分布的影响，这取决于刺激参数和目标区域。大多数LIFU研究集中于脑神经调节，而脊髓和周围神经的神经调节则有一些数据。结论：评价LIFU调节神经系统能力的研究已经出现了相当大的增长。虽然安全性和有效性已经得到证实，但LIFU操作参数的异质性可能会对靶组织产生细微的差异影响。通过进一步阐明LIFU神经调节的机制，未来的研究将推动慢性神经疾病的治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuromodulation 医学-临床神经学

CiteScore

6.40

自引率

3.60%

发文量

978

审稿时长

54 days

期刊介绍： Neuromodulation: Technology at the Neural Interface is the preeminent journal in the area of neuromodulation, providing our readership with the state of the art clinical, translational, and basic science research in the field. For clinicians, engineers, scientists and members of the biotechnology industry alike, Neuromodulation provides timely and rigorously peer-reviewed articles on the technology, science, and clinical application of devices that interface with the nervous system to treat disease and improve function.