Perioperative subconjunctival steroid injection in dropless cataract surgery: a systematic review and meta-analysis.

IF 1.2 4区医学 Q3 OPHTHALMOLOGY

Arquivos brasileiros de oftalmologia Pub Date : 2025-10-10 eCollection Date: 2025-01-01 DOI:10.5935/0004-2749.2024-0394

Laura Goldfarb Cyrino, Dillan Amaral, Alexandre Yamada Fujimura Júnior, Bela J Parekh, Marcela Marino de Azeredo Bastos, Giovana de Souza Gaio, Maria Antônia Torres Arteche, Amanda Souza do Nascimento, Vitor Expedito Alves Ribeiro, Jaime Guedes, Marianna Almeida Hollaender

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Abstract

The advantages and disadvantages of using perioperative subconjunctival steroid injections in dropless cataract surgery continue to be debated. A systematic review of PubMed, EMBASE, and the Cochrane Central database identified five studies-two randomized controlled trials and three non-randomized studies-encompassing 70,751 eyes. Among these, 12,319 eyes (17.4%) received subconjunctival steroid injections, while 58,432 eyes (82.6%) were managed with topical steroids. The Cochrane Collaboration's RoB 2 tool was applied for bias assessments in randomized controlled trials, and heterogeneity was assessed using the I² statistics. No statistically significant differences were found between the two groups regarding macular edema (p=0.249), visual acuity (p=0.73), or laser flare count (p=0.45). Both subconjunctival injections and topical steroids demonstrated comparable efficacy and safety in controlling postoperative inflammation after cataract surgery. Additional research is warranted to validate these conclusions.

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无滴白内障手术围手术期结膜下类固醇注射：系统回顾和荟萃分析。

在无滴白内障手术中使用围手术期结膜下类固醇注射的利弊仍在争论中。对PubMed、EMBASE和Cochrane中央数据库的系统回顾确定了5项研究——2项随机对照试验和3项非随机试验——包括70,751只眼睛。其中，12,319只眼（17.4%）接受了结膜下类固醇注射，58,432只眼（82.6%）接受了局部类固醇注射。随机对照试验采用Cochrane Collaboration的RoB 2工具进行偏倚评估，采用I²统计量评估异质性。两组在黄斑水肿（p=0.249）、视力（p=0.73）或激光耀斑计数（p=0.45）方面无统计学差异。结膜下注射和局部类固醇在控制白内障术后炎症方面具有相当的疗效和安全性。需要进一步的研究来证实这些结论。

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来源期刊

Arquivos brasileiros de oftalmologia OPHTHALMOLOGY-

CiteScore

1.60

自引率

0.00%

发文量

200

审稿时长

6-12 weeks

期刊介绍： The ABO-ARQUIVOS BRASILEIROS DE OFTALMOLOGIA (ABO, ISSN 0004-2749 - print and ISSN 1678-2925 - (ABO, ISSN 0004-2749 - print and ISSN 1678-2925 - electronic version), the official bimonthly publication of the Brazilian Council of Ophthalmology (CBO), aims to disseminate scientific studies in Ophthalmology, Visual Science and Health public, by promoting research, improvement and updating of professionals related to the field.