SURGICAL PROCEDURES PROLONG AMBULATION IN PATIENTS WITH DUCHENNE MUSCULAR DYSTROPHY.

IF 0.6 4区医学 Q4 ORTHOPEDICS

Acta Ortopedica Brasileira Pub Date : 2025-10-13 eCollection Date: 2025-09-01 DOI:10.1590/1413-785220253302e287732

David Gonçalves Nordon, Felipe Cruz Caetano Dos Reis, Carlos Alberto Dos Santos, Adilson DE Paula, Maria Bernadete Dutra DE Resende, Patricia Moreno Grangeiro

{"title":"SURGICAL PROCEDURES PROLONG AMBULATION IN PATIENTS WITH DUCHENNE MUSCULAR DYSTROPHY.","authors":"David Gonçalves Nordon, Felipe Cruz Caetano Dos Reis, Carlos Alberto Dos Santos, Adilson DE Paula, Maria Bernadete Dutra DE Resende, Patricia Moreno Grangeiro","doi":"10.1590/1413-785220253302e287732","DOIUrl":null,"url":null,"abstract":"Objective: The aim of this study was to evaluate the effect of surgical procedures on maintaining ambulation for Duchenne patients.Methods: This retrospective cohort study evaluated 35 patients for whom surgery was recommended at our institution from 2012 to 2020.Results: Twenty-seven patients were operated on before gait loss, and eight after. In this study, surgical treatment allowed recovery and prolongation of gait for 38.6 months, on average. The sooner the surgery was performed, the better the results were; logistic regression analysis showed that each day of delay after gait loss decreased the chances of success by 0.2%. The optimal interval for intervention was up to 12 months after gait loss.Conclusion: Our results thus corroborate the evidence that surgical interventions are beneficial for these patients and suggest a not previously described time window for achieving better outcomes. Level of Evidence lll; Retrospective, Comparative Study of Surgical Interventions.","PeriodicalId":55563,"journal":{"name":"Acta Ortopedica Brasileira","volume":"33 spe2","pages":"e287732"},"PeriodicalIF":0.6000,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12517556/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Ortopedica Brasileira","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1590/1413-785220253302e287732","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/9/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"ORTHOPEDICS","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: The aim of this study was to evaluate the effect of surgical procedures on maintaining ambulation for Duchenne patients.

Methods: This retrospective cohort study evaluated 35 patients for whom surgery was recommended at our institution from 2012 to 2020.

Results: Twenty-seven patients were operated on before gait loss, and eight after. In this study, surgical treatment allowed recovery and prolongation of gait for 38.6 months, on average. The sooner the surgery was performed, the better the results were; logistic regression analysis showed that each day of delay after gait loss decreased the chances of success by 0.2%. The optimal interval for intervention was up to 12 months after gait loss.

Conclusion: Our results thus corroborate the evidence that surgical interventions are beneficial for these patients and suggest a not previously described time window for achieving better outcomes. Level of Evidence lll; Retrospective, Comparative Study of Surgical Interventions.

查看原文本刊更多论文

外科手术延长杜氏肌营养不良患者的活动时间。

目的：本研究的目的是评估外科手术对杜氏症患者维持活动的影响。方法：本回顾性队列研究评估了2012年至2020年在我院推荐手术的35例患者。结果：失步前手术27例，失步后手术8例。在这项研究中，手术治疗使步态恢复和延长平均38.6个月。手术越早进行，效果越好；逻辑回归分析显示，步态丧失后每延迟一天，成功的机会降低0.2%。干预的最佳时间间隔为步态丧失后12个月。结论：因此，我们的研究结果证实了手术干预对这些患者有益的证据，并提出了一个以前没有描述的时间窗口来获得更好的结果。《证据水平》；手术干预的回顾性比较研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Acta Ortopedica Brasileira Orthopedics-

CiteScore

0.90

自引率

14.30%

发文量

审稿时长

25 weeks

期刊介绍： A Revista Acta Ortopédica Brasileira, órgão oficial do Departamento de Ortopedia e Traumatologia da Faculdade de Medicina da Universidade de São Paulo (DOT/FMUSP), é publicada bimestralmente em seis edições ao ano (jan/fev, mar/abr, maio/jun, jul/ago, set/out e nov/dez) com versão em inglês disponível nos principais indexadores nacionais e internacionais e instituições de ensino do Brasil. Sendo hoje reconhecidamente uma importante contribuição para os especialistas da área com sua seriedade e árduo trabalho para as indexações já conquistadas.