Conventional and Contrast-enhanced Ultrasound Imaging in 2 Human Kidney Xenotransplant Recipients.

IF 5 2区医学 Q1 IMMUNOLOGY

Transplantation Pub Date : 2025-10-15 DOI:10.1097/TP.0000000000005538

Sylvain Bodard, Amirkasra Mojtahed, Madeleine Sertic, Theodore T Pierce, Rory L Cochran, Reece J Goiffon, Leonardo V Riella

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引用次数: 0

Abstract

Background: Kidney xenotransplantation offers a promising novel solution to the global organ shortage, although the expected postoperative imaging characteristics remain undefined.

Methods: We report the first application of longitudinal grayscale, color, and spectral Doppler ultrasound in 2 human recipients of genetically engineered porcine kidney xenografts. One recipient additionally underwent serial contrast-enhanced ultrasound to assess parenchymal perfusion. Imaging findings were correlated with serum creatinine trajectories and biopsy-proven rejection.

Results: In both recipients, spectral Doppler abnormalities-including elevation in resistive index-preceded biopsy-confirmed T-cell-mediated rejection. Contrast-enhanced ultrasound in 1 recipient revealed delayed contrast enhancement that paralleled rejection and normalized with treatment. Neither graft demonstrated significant posttransplant growth, with observed changes in graft length remaining within the expected range for Yucatan miniature swine-derived kidneys.

Conclusions: These findings provide the first preliminary ultrasound-based insights into kidney xenograft vascular dynamics and growth patterns, underscoring the potential of ultrasound as an essential tool for noninvasive monitoring of kidney xenotransplants.

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2例异种肾移植受者的常规和增强超声成像分析。

背景：异种肾脏移植为全球器官短缺提供了一个有希望的新解决方案，尽管预期的术后影像学特征仍不明确。方法：我们报告了纵向灰度、彩色和频谱多普勒超声在2例人类基因工程猪肾异种移植受体中的首次应用。另一名受者接受了连续超声造影来评估实质灌注。影像学结果与血清肌酐轨迹和活检证实的排斥反应相关。结果：在两名受者中，谱多普勒异常-包括活检前抵抗指数升高-证实了t细胞介导的排斥反应。1名受者的超声造影显示延迟的造影增强，与排斥反应平行，并随着治疗而正常化。两种移植物均未表现出明显的移植后生长，观察到的移植物长度变化仍在尤卡坦微型猪源肾的预期范围内。结论：这些发现首次提供了基于超声的关于异种肾脏移植血管动力学和生长模式的初步见解，强调了超声作为无创监测异种肾脏移植的重要工具的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Transplantation 医学-免疫学

CiteScore

8.50

自引率

11.30%

发文量

1906

审稿时长

1 months

期刊介绍： The official journal of The Transplantation Society, and the International Liver Transplantation Society, Transplantation is published monthly and is the most cited and influential journal in the field, with more than 25,000 citations per year. Transplantation has been the trusted source for extensive and timely coverage of the most important advances in transplantation for over 50 years. The Editors and Editorial Board are an international group of research and clinical leaders that includes many pioneers of the field, representing a diverse range of areas of expertise. This capable editorial team provides thoughtful and thorough peer review, and delivers rapid, careful and insightful editorial evaluation of all manuscripts submitted to the journal. Transplantation is committed to rapid review and publication. The journal remains competitive with a time to first decision of fewer than 21 days. Transplantation was the first in the field to offer CME credit to its peer reviewers for reviews completed. The journal publishes original research articles in original clinical science and original basic science. Short reports bring attention to research at the forefront of the field. Other areas covered include cell therapy and islet transplantation, immunobiology and genomics, and xenotransplantation.