Chiral Lithium Amides as Key Reagents in Enantioselective Synthesis of 2-Alkylpyridines with Multiple Stereocenters.

IF 15.6 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Journal of the American Chemical Society Pub Date : 2025-10-15 DOI:10.1021/jacs.5c13977

Dyllan P Ly,Leroy Lu,Priya Kandiyal,Armen Zakarian

引用次数: 0

Abstract

A direct enantioselective conjugate addition of 2-alkylpyridines enables efficient construction of complex functionalized pyridinyl scaffolds with contiguous stereocenters. This method leverages chiral lithium amides as traceless stereodirecting auxiliaries, operating through defined aggregation of organolithium intermediates to achieve excellent enantio- and diastereocontrol.

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手性锂酰胺作为多立体中心2-烷基吡啶对映选择性合成的关键试剂。

2-烷基吡啶的直接对映选择性共轭加成可以高效地构建具有连续立体中心的复杂功能化吡啶基支架。该方法利用手性锂酰胺作为无迹立体定向助剂，通过有机锂中间体的特定聚集来实现出色的对映和非对映控制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the American Chemical Society 化学-化学综合

CiteScore

24.40

自引率

6.00%

发文量

2398

审稿时长

1.6 months

期刊介绍： The flagship journal of the American Chemical Society, known as the Journal of the American Chemical Society (JACS), has been a prestigious publication since its establishment in 1879. It holds a preeminent position in the field of chemistry and related interdisciplinary sciences. JACS is committed to disseminating cutting-edge research papers, covering a wide range of topics, and encompasses approximately 19,000 pages of Articles, Communications, and Perspectives annually. With a weekly publication frequency, JACS plays a vital role in advancing the field of chemistry by providing essential research.