Mitochondrial and psychosocial stress-related regulation of FGF21 in humans.

IF 20.8 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Nature metabolism Pub Date : 2025-10-14 DOI:10.1038/s42255-025-01388-6

Mangesh Kurade,Natalia Bobba-Alves,Catherine Kelly,Alexander Behnke,Quinn Conklin,Robert-Paul Juster,Michio Hirano,Caroline Trumpff,Martin Picard

引用次数: 0

Abstract

Fibroblast growth factor 21 (FGF21) is a metabolic hormone induced by fasting, metabolic stress and mitochondrial oxidative phosphorylation (OxPhos) defects that cause mitochondrial diseases (MitoD). Here we report that acute psychosocial stress alone (without physical exertion) decreases serum FGF21 by an average of 20% (P < 0.0001) in healthy controls, but increases FGF21 by 32% (P < 0.0001) in people with MitoD, pointing to a functional FGF21 interaction between the stress response and OxPhos capacity. We further define co-activation patterns between FGF21 and stress-related neuroendocrine hormones and report associations between FGF21 and psychosocial factors related to stress and wellbeing. Overall, these results highlight a potential role for FGF21 as a stress hormone involved in meeting the energetic needs of psychosocial stress.

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人类FGF21的线粒体和社会心理应激相关调控。

成纤维细胞生长因子21 （FGF21）是一种代谢激素，由禁食、代谢应激和线粒体氧化磷酸化（OxPhos）缺陷引起线粒体疾病（MitoD）。在这里，我们报告了急性社会心理应激（没有体力消耗）在健康对照中使血清FGF21平均降低20% (P < 0.0001)，但在MitoD患者中使FGF21增加32% (P < 0.0001)，这表明应激反应和OxPhos能力之间存在功能性FGF21相互作用。我们进一步定义了FGF21与压力相关的神经内分泌激素之间的共同激活模式，并报告了FGF21与压力和健康相关的社会心理因素之间的关联。总的来说，这些结果强调了FGF21作为一种压力激素参与满足心理社会压力的能量需求的潜在作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

27.50

自引率

2.40%

发文量

170

期刊介绍： Nature Metabolism is a peer-reviewed scientific journal that covers a broad range of topics in metabolism research. It aims to advance the understanding of metabolic and homeostatic processes at a cellular and physiological level. The journal publishes research from various fields, including fundamental cell biology, basic biomedical and translational research, and integrative physiology. It focuses on how cellular metabolism affects cellular function, the physiology and homeostasis of organs and tissues, and the regulation of organismal energy homeostasis. It also investigates the molecular pathophysiology of metabolic diseases such as diabetes and obesity, as well as their treatment. Nature Metabolism follows the standards of other Nature-branded journals, with a dedicated team of professional editors, rigorous peer-review process, high standards of copy-editing and production, swift publication, and editorial independence. The journal has a high impact factor, has a certain influence in the international area, and is deeply concerned and cited by the majority of scholars.