Immunohistochemical and histopathological characteristics of adenomas and adenocarcinomas of Meibomian glands in dogs.

IF 1.9 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Folia histochemica et cytobiologica Pub Date : 2025-01-01 Epub Date: 2025-10-14 DOI:10.5603/fhc.108299

Rafal Ciaputa, Adam Szymerowski, Kacper Zebrowski, Stanislaw Dzimira, Izabela Janus-Ziolkowska, Malgorzata Kandefer-Gola, Marcin Nowak

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引用次数: 0

Abstract

Introduction: This study aimed to provide a comprehensive histopathological and immunohistochemical analysis of Meibomian adenomas and adenocarcinomas.

Material and methods: A total of 80 tumours were included in the study: 33 adenomas and 47 Meibomian adenocarcinomas. Ki-67, cytokeratin-7 and von Willebrand factor antibodies were used for the immunohistochemical staining.

Results: Detailed characteristics of inflammatory infiltration depending on tumor type and damage to surrounding tissue by tumour cells are presented. A close correlation was found between the structure and intensity of blood vessel proliferation and the level of factor VIII expression.

Conclusions: The presented detailed histopathological analysis, combined with the results of immunohistochemical studies, now allows for better treatment planning and prognosis assessment for patients.

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犬睑板腺腺瘤和腺癌的免疫组织化学和组织病理学特征。

本研究旨在提供睑板腺瘤和腺癌的综合组织病理学和免疫组织化学分析。材料与方法：共纳入80例肿瘤：腺瘤33例，眉板腺癌47例。免疫组化染色采用Ki-67、细胞角蛋白-7和血管性血友病因子抗体。结果:。炎症浸润的详细特征取决于肿瘤类型和肿瘤细胞对周围组织的损害。血管增殖的结构和强度与因子VIII的表达水平密切相关。结论：详细的组织病理学分析，结合免疫组织化学研究结果，现在可以更好地为患者制定治疗计划和预后评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Folia histochemica et cytobiologica 生物-生化与分子生物学

CiteScore

2.80

自引率

6.70%

发文量

审稿时长

6-12 weeks

期刊介绍： "Folia Histochemica et Cytobiologica" is an international, English-language journal publishing articles in the areas of histochemistry, cytochemistry and cell & tissue biology. "Folia Histochemica et Cytobiologica" was established in 1963 under the title: ‘Folia Histochemica et Cytochemica’ by the Polish Histochemical and Cytochemical Society as a journal devoted to the rapidly developing fields of histochemistry and cytochemistry. In 1984, the profile of the journal was broadened to accommodate papers dealing with cell and tissue biology, and the title was accordingly changed to "Folia Histochemica et Cytobiologica". "Folia Histochemica et Cytobiologica" is published quarterly, one volume a year, by the Polish Histochemical and Cytochemical Society.