d-Serine’s Journey Between Stars and Synapses

IF 3.8 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Neurochemical Research Pub Date : 2025-10-14 DOI:10.1007/s11064-025-04564-y

Sarah Mountadem, Stéphane Henri Richard Oliet, Aude Panatier

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Abstract

Astrocytes play a pivotal role in regulating synaptic transmission, with d-serine emerging as a key gliotransmitter shaping NMDA receptor-dependent functions. This review is focusing on the multifaceted role of astrocytic d-serine from synaptic transmission to cognitive processes. While this review includes the work of other groups, it is mainly based on the findings obtained in our laboratory. Drawing from two decades of research spanning from the hypothalamus to the hippocampus, we here highlight how astrocyte-derived d-serine regulates NMDAR activity, long-term synaptic plasticity, and associated memory. Our findings have revealed the dynamic control exerted by astrocytic processes onto d-serine availability within the synaptic cleft, including the impact of the astrocytic morphological plasticity, the key role played by intracellular Ca²⁺ as well as the involvement of CB1 and EphB3 receptors. We also discuss how an impairment in astrocytic d-serine synthesis can affect the co-agonist availability and consequently impact cognitive functions in neurodegenerative disorders such as Alzheimer’s Disease. To conclude, this review highlights the role of astrocytic d-serine in astrocyte-neuron communication and higher-order brain functions.

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d -丝氨酸在恒星和突触之间的旅程。

星形胶质细胞在调节突触传递中起着关键作用，d -丝氨酸是形成NMDA受体依赖功能的关键胶质递质。本文就星形胶质细胞d -丝氨酸从突触传递到认知过程的多方面作用作一综述。虽然这篇综述包括了其他小组的工作，但它主要是基于我们实验室获得的发现。从下丘脑到海马体的二十年研究中，我们在这里强调了星形胶质细胞衍生的d -丝氨酸如何调节NMDAR活性、长期突触可塑性和相关记忆。我们的研究结果揭示了星形细胞过程对突触间隙内d -丝氨酸可用性的动态控制，包括星形细胞形态可塑性的影响，细胞内Ca2+的关键作用以及CB1和EphB3受体的参与。我们还讨论了星形胶质细胞d -丝氨酸合成的损伤如何影响协同激动剂的可用性，从而影响阿尔茨海默病等神经退行性疾病的认知功能。总之，本文综述了星形胶质细胞d -丝氨酸在星形胶质细胞-神经元通讯和高阶脑功能中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurochemical Research 医学-神经科学

CiteScore

7.70

自引率

2.30%

发文量

320

审稿时长

6 months

期刊介绍： Neurochemical Research is devoted to the rapid publication of studies that use neurochemical methodology in research on nervous system structure and function. The journal publishes original reports of experimental and clinical research results, perceptive reviews of significant problem areas in the neurosciences, brief comments of a methodological or interpretive nature, and research summaries conducted by leading scientists whose works are not readily available in English.