Gut-Derived Lipopolysaccharides and Metabolic Endotoxemia: A Critical Review.

IF 3.1 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

American journal of physiology. Endocrinology and metabolism Pub Date : 2025-10-13 DOI:10.1152/ajpendo.00355.2025

Bandy Chen, Laurent Gautron

引用次数: 0

Abstract

The metabolic endotoxemia hypothesis proposes that low levels of gut-derived lipopolysaccharides (LPS) act in a hormone-like manner to influence metabolism, contributing to obesity and dysregulation of glucose homeostasis. However, due to methodological limitations, it remains unclear whether a significant amount of bioactive gut-derived LPS reaches the bloodstream and, if so, whether it has a meaningful impact on metabolic processes. Additionally, there are several theoretical challenges regarding the coherence of the metabolic endotoxemia hypothesis, raising questions about its validity. Here, in the light of recent literature, we critically review arguments for and against the metabolic endotoxemia hypothesis.

查看原文本刊更多论文

肠源性脂多糖和代谢性内毒素血症：综述。

代谢性内毒素血症假说认为，低水平的肠源性脂多糖（LPS）以激素样方式影响代谢，导致肥胖和葡萄糖稳态失调。然而，由于方法学的限制，目前尚不清楚是否大量的生物活性肠道来源的LPS到达血液，如果是，它是否对代谢过程有意义的影响。此外，关于代谢内毒素血症假说的一致性存在一些理论挑战，对其有效性提出了质疑。在这里，根据最近的文献，我们批判性地回顾了支持和反对代谢内毒素血症假说的论点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

American journal of physiology. Endocrinology and metabolism 医学-内分泌学与代谢

CiteScore

9.80

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： The American Journal of Physiology-Endocrinology and Metabolism publishes original, mechanistic studies on the physiology of endocrine and metabolic systems. Physiological, cellular, and molecular studies in whole animals or humans will be considered. Specific themes include, but are not limited to, mechanisms of hormone and growth factor action; hormonal and nutritional regulation of metabolism, inflammation, microbiome and energy balance; integrative organ cross talk; paracrine and autocrine control of endocrine cells; function and activation of hormone receptors; endocrine or metabolic control of channels, transporters, and membrane function; temporal analysis of hormone secretion and metabolism; and mathematical/kinetic modeling of metabolism. Novel molecular, immunological, or biophysical studies of hormone action are also welcome.