Observational Study of Sublingual Microcirculation in Patients With Chronic Cardiovascular Disease

IF 2 4区医学 Q3 HEMATOLOGY

Microcirculation Pub Date : 2025-10-13 DOI:10.1111/micc.70032

Jacob Niculcea, James W. Schurr, Fatima M. Talebi, Joyce W. Wald, John C. Greenwood

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引用次数: 0

Abstract

Background

Sublingual video microscopy is increasingly used to study the microcirculation in acute illness. However, the sublingual microcirculation in patients with chronic cardiovascular diseases (CVD) is understudied. Our objective was to quantify sublingual microcirculatory parameters in a large cohort of patients with CVD.

Methods

One hundred and thirteen patients with CVD were enrolled. Incident dark-field handheld video microscopy (IDF-HVM) was used to quantify microvascular flow index (MFI), microvascular heterogeneity index (MHI), proportion of perfused vessels (PPV), perfused vessel density (PVD), and total vessel density (TVD). Data were stratified by age quartiles (20–39, 40–59, 60–79, 80+), cardiovascular comorbidities (hypertension, diabetes, chronic kidney disease, coronary artery disease, heart failure), and systemic hemodynamics (mean arterial pressure and pulse pressure).

Results

In our 113 patient cohort, overall MFI = 2.86 ± 0.20; MHI = 0.15 ± 0.20; PPV = 94.3% ± 4.9%; PVD = 23.1 ± 4.7 mm/mm²; and TVD = 24.5 ± 4.8 mm/mm². Diabetic patients had lower mean MHI (0.10 vs. 0.17; p = 0.046) compared to those without diabetes. There was no difference in sublingual parameters attributable to other CVDs, age, or hemodynamics.

Conclusion

In patients with stable cardiovascular disease, sublingual microvascular parameters are similar across age, blood pressure, and comorbidity cohorts, with the exception of decreased MHI in diabetic patients.

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慢性心血管疾病患者舌下微循环的观察研究。

背景：舌下视频显微镜越来越多地用于研究急性疾病的微循环。然而，慢性心血管疾病（CVD）患者的舌下微循环尚未得到充分研究。我们的目的是量化一大群CVD患者的舌下微循环参数。方法：纳入113例CVD患者。采用入射暗场手持式视频显微镜（IDF-HVM）对微血管流动指数（MFI）、微血管异质性指数（MHI）、灌注血管比例（PPV）、灌注血管密度（PVD）、总血管密度（TVD）进行量化。数据按年龄四分位数（20-39岁、40-59岁、60-79岁、80岁以上）、心血管合并症（高血压、糖尿病、慢性肾病、冠状动脉疾病、心力衰竭）和全身血流动力学（平均动脉压和脉压）进行分层。结果：在113例患者队列中，总体MFI = 2.86±0.20；mhi = 0.15±0.20；ppv = 94.3%±4.9%；PVD = 23.1±4.7 mm/mm2；TVD = 24.5±4.8 mm/mm2。与非糖尿病患者相比，糖尿病患者的平均MHI较低（0.10 vs. 0.17; p = 0.046）。其他心血管疾病、年龄或血流动力学引起的舌下参数没有差异。结论：在稳定性心血管疾病患者中，除了糖尿病患者的MHI降低外，舌下微血管参数在年龄、血压和合并症队列中相似。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microcirculation 医学-外周血管病

CiteScore

5.00

自引率

4.20%

发文量

审稿时长

6-12 weeks

期刊介绍： The journal features original contributions that are the result of investigations contributing significant new information relating to the vascular and lymphatic microcirculation addressed at the intact animal, organ, cellular, or molecular level. Papers describe applications of the methods of physiology, biophysics, bioengineering, genetics, cell biology, biochemistry, and molecular biology to problems in microcirculation. Microcirculation also publishes state-of-the-art reviews that address frontier areas or new advances in technology in the fields of microcirculatory disease and function. Specific areas of interest include: Angiogenesis, growth and remodeling; Transport and exchange of gasses and solutes; Rheology and biorheology; Endothelial cell biology and metabolism; Interactions between endothelium, smooth muscle, parenchymal cells, leukocytes and platelets; Regulation of vasomotor tone; and Microvascular structures, imaging and morphometry. Papers also describe innovations in experimental techniques and instrumentation for studying all aspects of microcirculatory structure and function.