Colchicine Only Inhibits in Higher Doses Hyperactivated NLRP3 Inflammasome-The Main Respondent for Complications in COVID-19 and Influenza.

Abstract

Despite the enormous theoretical progress, there is currently no effective treatment for the cytokine storm (CS) in COVID-19 and Influenza, which is due to hyperactivation of NOD-like receptor protein 3 inflammasome (NLRP3-I). According to our research, the only way to prevent or interrupt the CS is to administer high but safe doses of colchicine, which inhibits NLRP3-I/CS.