Epigenetic modulation of CTCs as a novel therapeutic target in oncology.

IF 3.7 2区生物学 Q3 CELL BIOLOGY

Molecular and Cellular Biochemistry Pub Date : 2025-10-11 DOI:10.1007/s11010-025-05402-z

Husni Farah, Munther Kadhim Abosaoda, Hayjaa Mohaisen Mousa, S Renuka Jyothi, Priya Priyadarshini Nayak, J Bethanney Janney, Gurjant Singh, Ashish Singh Chauhan

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Abstract

Tumor metastasis is the primary cause of high mortality rates among cancer patients. Invasive tumor cells disseminate through the bloodstream as circulating tumor cells (CTCs) and subsequently colonize secondary organs. In addition to genetic mutations that govern biological processes, epigenetic alterations also regulate tumor cell gene expression and chromosome stability. Dysregulation of these patterns is pivotal to carcinogenesis, tumor progression, and metastasis. This narrative review initiates with a comprehensive overview of the biology of CTCs and the processes that contribute to epithelial-mesenchymal transition (EMT), immune surveillance, and colonization. Subsequently, the impact of epigenetic modifications in CTCs on these metastatic processes during CTC migration, survival, and dissemination will be examined. In addition, the paper presents the implications of targeting epigenetics in CTCs for cancer patients and introduces CTCs as new biomarkers for early detection, prognosis, and targeted therapies to improve patient outcomes.

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ctc的表观遗传调控作为肿瘤治疗的新靶点。

肿瘤转移是癌症患者高死亡率的主要原因。侵袭性肿瘤细胞作为循环肿瘤细胞（ctc）通过血液传播，随后定植于次要器官。除了控制生物过程的基因突变外，表观遗传改变还调节肿瘤细胞基因表达和染色体稳定性。这些模式的失调是致癌、肿瘤进展和转移的关键。本文首先对ctc的生物学和上皮-间质转化（EMT）、免疫监视和定植的过程进行了全面的概述。随后，将研究CTC表观遗传修饰对CTC迁移、生存和传播过程中这些转移过程的影响。此外，本文还介绍了靶向表观遗传学在CTCs中对癌症患者的意义，并介绍了CTCs作为早期检测、预后和靶向治疗的新生物标志物，以改善患者的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular and Cellular Biochemistry 生物-细胞生物学

CiteScore

8.30

自引率

2.30%

发文量

293

审稿时长

1.7 months

期刊介绍： Molecular and Cellular Biochemistry: An International Journal for Chemical Biology in Health and Disease publishes original research papers and short communications in all areas of the biochemical sciences, emphasizing novel findings relevant to the biochemical basis of cellular function and disease processes, as well as the mechanics of action of hormones and chemical agents. Coverage includes membrane transport, receptor mechanism, immune response, secretory processes, and cytoskeletal function, as well as biochemical structure-function relationships in the cell. In addition to the reports of original research, the journal publishes state of the art reviews. Specific subjects covered by Molecular and Cellular Biochemistry include cellular metabolism, cellular pathophysiology, enzymology, ion transport, lipid biochemistry, membrane biochemistry, molecular biology, nuclear structure and function, and protein chemistry.