Evaluation of osteoporosis in adult patients with beta-thalassemia major and its relation to serum sclerostin level

IF 2.6 4区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Clinics and research in hepatology and gastroenterology Pub Date : 2025-11-01 Epub Date: 2025-10-10 DOI:10.1016/j.clinre.2025.102709

Ahmed Abd El Fattah El Bamby , Tamer Abd El Hamid El bedawi , Mohammed Adel Eltomi , Sara Mamdouh Shoeeb , Enji Abd El Wahab Ibrahim

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引用次数: 0

Abstract

Background

Beta-thalassemia major (β-TM) is a chronic hemoglobinopathy in which improved survival has shifted focus toward long-term complications, notably osteoporosis. The pathogenesis is multifactorial, involving iron overload, bone marrow expansion, endocrine dysfunction, and impaired osteoblast activity. While histomorphometric data highlight reduced bone formation, clinical evidence demonstrates broader and more severe skeletal abnormalities.

Purpose of study

To evaluate osteoporosis in β-TM patients and examine its relationship with serum sclerostin levels.

Methods

This study employed a cross-sectional case-control design. Enrolled 80 individuals diagnosed with β-TM. Participants were equally assigned to two groups: Group I, consisting of β-TM patients, and Group II, composed of healthy controls matched for age and sex.

Results

Serum sclerostin significantly predict osteoporosis among the tested patients (P < 0.001 and AUC = 0.868) at cut-off>0.61 with 80 %sensitivity, 80 %specificity. T score exhibited significantly lower value in beta TM (group I) when compared to control (group II) (P < 0.001). The poorly chelated group exhibited significantly higher T-scores and serum sclerostin levels. In univariate regression, (hemoglobin, transferrin saturation, serum iron, serum ferritin, total iron binding capacity and serum sclerostin) were independent predictors of osteoporosis β TM patients (P < 0.05). In Multivariate regression, serum sclerostin was independent predictor of osteoporosis in β- TM patients (P = 0.02) while weight, height, BMI, WBCs, Platelets, transferrin saturation, serum iron, ferritin were not.

Conclusions

Patients with β-TM exhibit a greater prevalence of osteoporosis and elevated serum sclerostin levels compared to healthy individuals. The increased serum sclerostin in β-TM patients may reflect impaired bone formation and increased bone loss, thus facilitating osteoporosis development.

查看原文本刊更多论文

重度β -地中海贫血成年患者骨质疏松及其与血清硬化蛋白水平的关系。

背景：β-地中海贫血（β-TM）是一种慢性血红蛋白病，其生存率的提高已转向长期并发症，特别是骨质疏松症。其发病机制是多因素的，包括铁超载、骨髓扩张、内分泌功能障碍和成骨细胞活性受损。虽然组织形态学数据强调骨形成减少，但临床证据显示更广泛和更严重的骨骼异常。研究目的：探讨β-TM患者骨质疏松及其与血清硬化素水平的关系。方法：本研究采用横断面病例-对照设计。招募了80名被诊断为β-TM的个体。参与者被平均分为两组：第一组由β-TM患者组成，第二组由年龄和性别匹配的健康对照组组成。结果：血清硬化蛋白可显著预测骨质疏松症（P0.61，敏感性80%，特异性80%）。与对照组（II组）相比，β-TM患者的T评分明显降低(p结论：β-TM患者骨质疏松症患病率更高，血清硬化蛋白水平升高。β-TM患者血清硬化蛋白升高可能反映了骨形成受损和骨质流失增加，从而促进骨质疏松症的发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinics and research in hepatology and gastroenterology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

4.30

自引率

3.70%

发文量

198

审稿时长

42 days

期刊介绍： Clinics and Research in Hepatology and Gastroenterology publishes high-quality original research papers in the field of hepatology and gastroenterology. The editors put the accent on rapid communication of new research and clinical developments and so called "hot topic" issues. Following a clear Editorial line, besides original articles and case reports, each issue features editorials, commentaries and reviews. The journal encourages research and discussion between all those involved in the specialty on an international level. All articles are peer reviewed by international experts, the articles in press are online and indexed in the international databases (Current Contents, Pubmed, Scopus, Science Direct). Clinics and Research in Hepatology and Gastroenterology is a subscription journal (with optional open access), which allows you to publish your research without any cost to you (unless you proactively chose the open access option). Your article will be available to all researchers around the globe whose institution has a subscription to the journal.