Duramycin: Exploring the therapeutic frontier of a unique lantibiotic

IF 3.5 4区医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Peptides Pub Date : 2025-11-01 Epub Date: 2025-10-11 DOI:10.1016/j.peptides.2025.171447

Meng Yuan , Shuaiming Bao , Kejun Wu , Zixin Deng , Jiangtao Gao

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Abstract

This review evaluates duramycin, a lantibiotic antimicrobial peptide, focusing on its biochemical properties, biosynthetic mechanisms, structural characteristics, and therapeutic applications. We examine the critical role of lanthionine and methyllanthionine in antimicrobial efficacy and trace duramycin's development trajectory. Molecular analysis of duramycin highlights the significance of post-translational modifications and leader peptide interactions in its functionality. The peptide's mechanism of action, which involves disrupting membrane integrity through phosphatidylethanolamine binding, forms the foundation of its antimicrobial activity. We assess duramycin's clinical progress, particularly its advancement to Phase II trials for cystic fibrosis therapy, and evaluate its potential against viral infections. The review addresses challenges in production, resistance development, and clinical delivery while exploring emerging applications in cancer treatment, diagnostics, and molecular probes for studying membrane dynamics. We conclude by examining future directions for lantibiotic engineering and the broader implications of duramycin research for antimicrobial therapy and biomedicine.

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杜拉霉素：探索一种独特抗生素的治疗前沿

本文综述了一种新型抗菌肽杜拉米霉素的生物化学特性、生物合成机制、结构特点和治疗应用。我们研究了硫代氨酸和甲基硫代氨酸在抗菌功效中的关键作用，并追踪了杜拉霉素的发展轨迹。杜拉霉素的分子分析强调了翻译后修饰和先导肽相互作用在其功能中的重要性。肽的作用机制包括通过磷脂酰乙醇胺结合破坏膜的完整性，这是其抗菌活性的基础。我们评估了duramycin的临床进展，特别是其用于囊性纤维化治疗的II期试验的进展，并评估了其抗病毒感染的潜力。这篇综述讨论了在生产、耐药发展和临床递送方面的挑战，同时探索了在癌症治疗、诊断和研究膜动力学的分子探针方面的新兴应用。最后，我们探讨了抗生素工程的未来方向，以及杜拉霉素研究在抗菌治疗和生物医学方面的更广泛意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Peptides 医学-生化与分子生物学

CiteScore

6.40

自引率

6.70%

发文量

130

审稿时长

28 days

期刊介绍： Peptides is an international journal presenting original contributions on the biochemistry, physiology and pharmacology of biological active peptides, as well as their functions that relate to gastroenterology, endocrinology, and behavioral effects. Peptides emphasizes all aspects of high profile peptide research in mammals and non-mammalian vertebrates. Special consideration can be given to plants and invertebrates. Submission of articles with clinical relevance is particularly encouraged.