The association between abnormal glucose metabolism and rheumatoid arthritis

IF 4.1 4区医学 Q2 PATHOLOGY

Experimental and molecular pathology Pub Date : 2025-12-01 Epub Date: 2025-10-11 DOI:10.1016/j.yexmp.2025.105001

Xiaoyu Zhang, Fanyan Meng, Zhidan Wang, Shuang Ren, Jie Zhang

{"title":"The association between abnormal glucose metabolism and rheumatoid arthritis","authors":"Xiaoyu Zhang, Fanyan Meng, Zhidan Wang, Shuang Ren, Jie Zhang","doi":"10.1016/j.yexmp.2025.105001","DOIUrl":null,"url":null,"abstract":"<div><div>The research has found that the incidence of rheumatoid arthritis (RA) combined with Type 2 Diabetes Mellitus (T2DM) and insulin resistance (IR) is higher than that in the general population. This indicates that there is an association mechanism between RA and abnormal glucose metabolism. IR is one of the main causes of T2DM, and high blood glucose levels are one of the main symptoms of T2DM. Therefore, revealing the intrinsic mechanism between RA and the abnormal glucose metabolism in T2DM becomes the key to treating RA complicated with T2DM. This article summarizes the mechanism of RA combined with T2DM, which is mainly caused by the disorder of glucose metabolism and the persistent presence of inflammatory mediators. The synovial hyperplasia, angiogenesis and bone destruction of RA interact with the abnormal glucose metabolism. Therefore, elaborating the intrinsic connection and interaction mechanism between abnormal glucose metabolism and RA, and summarizing the abnormal glucose metabolism phenomenon of increased prevalence of T2DM in RA patients in clinical practice, can provide a reference for future in-depth research on treatment plans related to abnormal glucose metabolism in RA.</div></div>","PeriodicalId":12176,"journal":{"name":"Experimental and molecular pathology","volume":"144 ","pages":"Article 105001"},"PeriodicalIF":4.1000,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Experimental and molecular pathology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0014480025000516","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/10/11 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"PATHOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

The research has found that the incidence of rheumatoid arthritis (RA) combined with Type 2 Diabetes Mellitus (T2DM) and insulin resistance (IR) is higher than that in the general population. This indicates that there is an association mechanism between RA and abnormal glucose metabolism. IR is one of the main causes of T2DM, and high blood glucose levels are one of the main symptoms of T2DM. Therefore, revealing the intrinsic mechanism between RA and the abnormal glucose metabolism in T2DM becomes the key to treating RA complicated with T2DM. This article summarizes the mechanism of RA combined with T2DM, which is mainly caused by the disorder of glucose metabolism and the persistent presence of inflammatory mediators. The synovial hyperplasia, angiogenesis and bone destruction of RA interact with the abnormal glucose metabolism. Therefore, elaborating the intrinsic connection and interaction mechanism between abnormal glucose metabolism and RA, and summarizing the abnormal glucose metabolism phenomenon of increased prevalence of T2DM in RA patients in clinical practice, can provide a reference for future in-depth research on treatment plans related to abnormal glucose metabolism in RA.

查看原文本刊更多论文

糖代谢异常与类风湿关节炎的关系

研究发现，类风湿关节炎（RA）合并2型糖尿病（T2DM）和胰岛素抵抗（IR）的发病率高于一般人群。这表明RA与糖代谢异常之间存在关联机制。IR是T2DM的主要病因之一，高血糖是T2DM的主要症状之一。因此，揭示RA与T2DM糖代谢异常之间的内在机制成为治疗RA合并T2DM的关键。本文综述了RA合并T2DM的发病机制，主要由糖代谢紊乱和炎症介质的持续存在引起。RA的滑膜增生、血管生成和骨破坏与糖代谢异常相互作用。因此，阐述糖代谢异常与RA的内在联系和相互作用机制，总结临床实践中RA患者T2DM患病率增高的糖代谢异常现象，可为今后深入研究RA糖代谢异常相关治疗方案提供参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Experimental and molecular pathology 医学-病理学

CiteScore

8.90

自引率

0.00%

发文量

审稿时长

11.5 weeks

期刊介绍： Under new editorial leadership, Experimental and Molecular Pathology presents original articles on disease processes in relation to structural and biochemical alterations in mammalian tissues and fluids and on the application of newer techniques of molecular biology to problems of pathology in humans and other animals. The journal also publishes selected interpretive synthesis reviews by bench level investigators working at the "cutting edge" of contemporary research in pathology. In addition, special thematic issues present original research reports that unravel some of Nature''s most jealously guarded secrets on the pathologic basis of disease. Research Areas include: Stem cells; Neoangiogenesis; Molecular diagnostics; Polymerase chain reaction; In situ hybridization; DNA sequencing; Cell receptors; Carcinogenesis; Pathobiology of neoplasia; Complex infectious diseases; Transplantation; Cytokines; Flow cytomeric analysis; Inflammation; Cellular injury; Immunology and hypersensitivity; Athersclerosis.