Graphene and its derivatives as surface-enhanced Raman spectroscopy substrates for glucose detection

IF 6.8 3区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Journal of Science: Advanced Materials and Devices Pub Date : 2025-09-30 DOI:10.1016/j.jsamd.2025.101015

Laila S. Alqarni , Maha D. Alghamdi

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Abstract

Diabetes mellitus has become a public health problem over recent years. This medical condition requires constant monitoring of glucose levels in the blood. Even though glucose produces a weak Raman signal, it is not sufficient for sensitive detection. Surface-enhanced Raman spectroscopy (SERS) is a non-invasive glucose testing method that will improve the detection limit and improve point of care services. An ideal substrate for SERS is still a subject of debate. Although metallic nanoparticles made of silver or gold can greatly enhance the intensity of Raman scattering, they have their limitations. Graphene has been proposed as an inert and stable alternative, although it has a lower enhancement factor and is difficult to produce. In recent studies, researchers have combined graphene and its derivatives with metallic nanoparticles to harness the advantages of both materials. Such a combination, along with modifications and different fabrication techniques, can enable glucose detection at very low concentrations (down to 10⁻¹² -10⁻¹⁴ M). This review provides an overview of the principle of SERS and covers recently developed graphene-based substrates for SERS analysis of glucose,along with their advantages and disadvantages.

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石墨烯及其衍生物作为葡萄糖检测的表面增强拉曼光谱底物

近年来，糖尿病已成为一个公共卫生问题。这种疾病需要持续监测血液中的葡萄糖水平。即使葡萄糖产生微弱的拉曼信号，它也不足以进行灵敏的检测。表面增强拉曼光谱（SERS）是一种非侵入性的葡萄糖检测方法，将提高检测限并改善护理点服务。SERS的理想底物仍然是一个有争议的话题。虽然由银或金制成的金属纳米粒子可以大大增强拉曼散射的强度，但它们也有局限性。石墨烯被认为是一种惰性和稳定的替代品，尽管它具有较低的增强因子并且难以生产。在最近的研究中，研究人员将石墨烯及其衍生物与金属纳米颗粒结合起来，以利用这两种材料的优点。这样的组合，以及修改和不同的制造技术，可以在非常低的浓度（低至10−12 -10−14 M）下进行葡萄糖检测。本文综述了SERS的原理，并介绍了最近开发的用于葡萄糖SERS分析的石墨烯基底物，以及它们的优缺点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Science: Advanced Materials and Devices Materials Science-Electronic, Optical and Magnetic Materials

CiteScore

11.90

自引率

2.50%

发文量

审稿时长

47 days

期刊介绍： In 1985, the Journal of Science was founded as a platform for publishing national and international research papers across various disciplines, including natural sciences, technology, social sciences, and humanities. Over the years, the journal has experienced remarkable growth in terms of quality, size, and scope. Today, it encompasses a diverse range of publications dedicated to academic research. Considering the rapid expansion of materials science, we are pleased to introduce the Journal of Science: Advanced Materials and Devices. This new addition to our journal series offers researchers an exciting opportunity to publish their work on all aspects of materials science and technology within the esteemed Journal of Science. With this development, we aim to revolutionize the way research in materials science is expressed and organized, further strengthening our commitment to promoting outstanding research across various scientific and technological fields.