RaabPhos, an Air-Stable, Highly Active Ferrocenyl Phosphasilinane Ligand, for Palladium-Catalyzed C-C and C-N Bond-Forming Cross-Coupling Reactions.

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-10-11 DOI:10.1021/acs.orglett.5c03832

Michael G Raab,Oliver Trapp,Dino Berthold

引用次数: 0

Abstract

The air-stable, highly active ferrocenyl phosphasilinane ligand RaabPhos has been synthesized in four steps from readily available starting materials. Although the ligand is not sterically overloaded, it is highly electron-rich and therefore the corresponding Pd catalyst of high activity. Furthermore, RaabPhos is air-stable as a solid as well as in solution. With the application of this novel ligand in various Pd-catalyzed C-C and C-N bond-forming cross-coupling reactions, its reactivity toward unreactive (hetero)aryl chlorides has been explored. We observed, in general, high yields in these transformations under mild conditions.

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RaabPhos，一种空气稳定、高活性的二茂铁基磷酸硅烷配体，用于钯催化的C-C和C-N键形成交叉偶联反应。

以现成的原料为原料，通过四个步骤合成了空气稳定、高活性的二茂铁基磷酸硅烷配体RaabPhos。虽然配体没有空间过载，但它是高度富电子的，因此相应的钯催化剂具有高活性。此外，RaabPhos在固体和溶液中都具有空气稳定性。随着该新型配体在各种pd催化的C-C和C-N成键交叉偶联反应中的应用，研究了其对非反应性（杂）芳酰氯的反应性。一般来说，在温和的条件下，我们观察到这些转化的高产率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.