Psychopathology and the autonomic nervous system in borderline personality disorder. Part 2. The Influence of Early Adversities, Dissociation and Self-stigma on the Treatment.

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Neuro endocrinology letters Pub Date : 2025-09-29
Vlastimil Nesnidal, Jan Prasko, Kamila Belohradova, Jakub Vanek, Frantisek Hodny, Milos Slepecky, Marie Ociskova
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Abstract

Introduction: This study examines the influence of childhood adversities, dissociation, and self-stigma on autonomic nervous system function and treatment outcomes in hospitalised patients with borderline personality disorder (BPD).

Methods: Seventy-five BPD inpatients underwent a six-week intensive psychotherapy treatment program. Changes in psychopathology and autonomic nervous system function were monitored. (heart rate variability, LF/HF ratio).

Results: The study confirmed a positive impact of the treatment program on reducing BPD symptomatology, anxiety, and depressive symptoms. Findings indicate that the initial dissociation level does not correlate with changes in symptomatology. In contrast, changes in dissociation during treatment are associated with reductions in anxiety and depressive symptoms. Regarding HRV, our data show that although there were no significant changes in HRV during treatment, higher baseline LF/HF values correlated with smaller changes in symptom severity, which could indicate a possible link between autonomic nervous dysregulation and the stability of BPD symptoms.

Discussion: Our findings emphasise the importance of monitoring physiological and psychological factors in BPD treatment, highlighting potential predictors of therapeutic response.

边缘型人格障碍的精神病理与自主神经系统。第2部分。早期逆境、分离和自我耻辱感对治疗的影响。
本研究探讨了童年逆境、分离和自我耻辱对边缘型人格障碍(BPD)住院患者自主神经系统功能和治疗结果的影响。方法:75例BPD住院患者接受为期6周的强化心理治疗方案。监测精神病理和自主神经系统功能的变化。(心率变异性,LF/HF比值)。结果:研究证实了治疗方案对减少BPD症状、焦虑和抑郁症状的积极影响。研究结果表明,初始游离水平与症状变化无关。相反,治疗期间分离的改变与焦虑和抑郁症状的减轻有关。关于HRV,我们的数据显示,虽然治疗期间HRV没有明显变化,但较高的基线LF/HF值与症状严重程度的较小变化相关,这可能表明自主神经失调与BPD症状的稳定性之间可能存在联系。讨论:我们的研究结果强调了监测BPD治疗中生理和心理因素的重要性,强调了治疗反应的潜在预测因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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