Vimig: The virus-induced migrasome as a novel mechanism for viral transmission and communication.

IF 4.9 1区医学 Q1 MICROBIOLOGY

PLoS Pathogens Pub Date : 2025-10-09 eCollection Date: 2025-10-01 DOI:10.1371/journal.ppat.1013557

Mingyan Feng, Leiliang Zhang

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引用次数: 0

Abstract

Vimig, defined as "virus-induced migrasome," represents a novel class of extracellular vesicles that originate from virus-infected cells. The mechanisms underlying vimig formation involve actin remodeling and upregulation of phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2). Vimig not only encapsulates viral particles but also aids in the transport of damaged organelles, including mitochondria, thereby contributing to cellular homeostasis and potentially enhancing viral spread and infection. Characterized by their unique contents, which includes viral particles, lipids, proteins, and cellular debris, vimig serves as a transmission route for viruses, possibly allowing them to evade host immune responses. This pearl summarizes the biogenesis, functional significance, and implications of vimig in viral pathogenesis, emphasizing its potential as a target for therapeutic interventions aimed at mitigating viral infections. Understanding the role of vimig may pave the way for novel strategies in clinical drug development and deepen our insights into virus-host interactions.

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Vimig：病毒诱导的迁移体是一种新的病毒传播和交流机制。

Vimig，被定义为“病毒诱导的迁移体”，代表了一类新的细胞外囊泡，起源于病毒感染的细胞。vimig形成的机制涉及肌动蛋白重塑和磷脂酰肌醇(4,5)-二磷酸（PI(4,5)P2）的上调。viimig不仅可以包裹病毒颗粒，还可以帮助受损细胞器（包括线粒体）的运输，从而有助于细胞稳态，并可能增强病毒的传播和感染。viimig的特点是其独特的内容，包括病毒颗粒、脂质、蛋白质和细胞碎片，viimig作为病毒的传播途径，可能使它们逃避宿主的免疫反应。本文总结了vimig在病毒发病机制中的生物发生、功能意义和意义，强调了其作为缓解病毒感染的治疗干预靶点的潜力。了解vimig的作用可能会为临床药物开发的新策略铺平道路，并加深我们对病毒-宿主相互作用的认识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

PLoS Pathogens MICROBIOLOGY-PARASITOLOGY

自引率

3.00%

发文量

598

期刊介绍： Bacteria, fungi, parasites, prions and viruses cause a plethora of diseases that have important medical, agricultural, and economic consequences. Moreover, the study of microbes continues to provide novel insights into such fundamental processes as the molecular basis of cellular and organismal function.