{"title":"Combined molecular mismatch scores for immunologic risk stratification in pediatric heart transplantation.","authors":"Mitchell A Ellison, Qingyong Xu, Adriana Zeevi","doi":"10.1097/MOT.0000000000001255","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose of review: </strong>This article will review the use of HLA molecular mismatch algorithms to predict the risk of de-novo DSA and rejection in pediatric heart transplant recipients. Here, we will focus on results obtained using the combined algorithm approach pairing HLAMatchmaker or HLA-EMMA with PIRCHE-II.</p><p><strong>Recent findings: </strong>The combined algorithm approach was recently used to assess risk of de-novo DSA and rejection in a pediatric heart transplant cohort from Clinical Trials in Organ Transplant in Children 04/09. This approach to analyzing HLA molecular mismatch data allowed for a more granular assessment of de-novo DSA and rejection risk than any individual algorithm.</p><p><strong>Summary: </strong>Advances in HLA molecular mismatch methods may enable personalized immunosuppression management that improves outcomes of pediatric heart transplant recipients.</p>","PeriodicalId":10900,"journal":{"name":"Current Opinion in Organ Transplantation","volume":" ","pages":"418-424"},"PeriodicalIF":2.5000,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Organ Transplantation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/MOT.0000000000001255","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/10/3 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"TRANSPLANTATION","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose of review: This article will review the use of HLA molecular mismatch algorithms to predict the risk of de-novo DSA and rejection in pediatric heart transplant recipients. Here, we will focus on results obtained using the combined algorithm approach pairing HLAMatchmaker or HLA-EMMA with PIRCHE-II.
Recent findings: The combined algorithm approach was recently used to assess risk of de-novo DSA and rejection in a pediatric heart transplant cohort from Clinical Trials in Organ Transplant in Children 04/09. This approach to analyzing HLA molecular mismatch data allowed for a more granular assessment of de-novo DSA and rejection risk than any individual algorithm.
Summary: Advances in HLA molecular mismatch methods may enable personalized immunosuppression management that improves outcomes of pediatric heart transplant recipients.
期刊介绍：
Current Opinion in Organ Transplantation is an indispensable resource featuring key, up-to-date and important advances in the field from around the world. Led by renowned guest editors for each section, every bimonthly issue of Current Opinion in Organ Transplantation delivers a fresh insight into topics such as stem cell transplantation, immunosuppression, tolerance induction and organ preservation and procurement. With 18 sections in total, the journal provides a convenient and thorough review of the field and will be of interest to researchers, surgeons and other healthcare professionals alike.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
