Traditional Chinese medicine use and risk of type 2 diabetes mellitus among patients with prediabetes: a population-based cohort study.

IF 5.7 3区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Chinese Medicine Pub Date : 2025-10-10 DOI:10.1186/s13020-025-01214-x

Zilin Long, Houyu Zhao, Yueqi Yin, Yexiang Sun, Peng Shen, Hongbo Lin, Junchang Liu, Siyan Zhan, Zhiqin Jiang, Feng Sun

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引用次数: 0

Abstract

Background: Prediabetes was a reversible process in the development of type 2 diabetes mellitus (T2DM). Traditional Chinese medicine (TCM) was used to regulate blood glucose for thousands of years. However, there was a lack of real-world evidence on the long-term impact of TCM in prediabetic populations. This study aimed to evaluate the association between the use of TCM and T2DM incidence among individuals with prediabetes.

Methods: A long-term population-based cohort study of participants with prediabetes was conducted using the Yinzhou Regional Health Care Database (YRHCD). A cox model with propensity score (PS) matching was applied to estimate the hazard ratio (HR) of the association between the use of TCM and T2DM. Various subgroup analyses and multiple sensitivity analyses were also performed to demonstrate the robustness of results.

Results: A total of 14,164 patients with prediabetes were included from the YRHCD between 2009 and 2024, among whom 12,252 participants were TCM users and 1912 initiated western medications (WM). In the primary analysis, the incidence of T2DM was 33.95 and 94.85 per 1000 person-years in users of TCM and WM, respectively. TCM use was associated with a significantly lower risk of developing T2DM (HR 0.32 [95%CI 0.27, 0.38]) after controlling confounding using PS matching. The results were generally consistent in various subgroup analyses and sensitivity analyses.

Conclusion: Use of TCM was associated with a decreased T2DM incidence in patients with prediabetes in the study region.

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糖尿病前期患者中药使用与2型糖尿病风险：一项基于人群的队列研究

背景：糖尿病前期是2型糖尿病（T2DM）发展的一个可逆过程。几千年来，人们一直用中医来调节血糖。然而，中药对糖尿病前期人群的长期影响缺乏实际证据。本研究旨在评估在糖尿病前期患者中使用中药与2型糖尿病发病率之间的关系。方法：利用鄞州地区卫生保健数据库（YRHCD）对糖尿病前期患者进行长期人群队列研究。采用倾向评分（PS）匹配的cox模型估计中药与2型糖尿病相关的风险比（HR）。还进行了各种亚组分析和多重敏感性分析，以证明结果的稳健性。结果：2009年至2024年，该研究共纳入14164例糖尿病前期患者，其中中药使用者12252例，西药起始者1912例。在初步分析中，T2DM的发病率在中西医结合人群中分别为33.95和94.85 / 1000人年。在使用PS匹配控制混杂后，使用中药与发生T2DM的风险显著降低相关（HR 0.32 [95%CI 0.27, 0.38]）。各亚组分析和敏感性分析结果基本一致。结论：中药治疗与研究地区糖尿病前期患者T2DM发病率降低相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chinese Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-PHARMACOLOGY & PHARMACY

CiteScore

7.90

自引率

4.10%

发文量

133

审稿时长

31 weeks

期刊介绍： Chinese Medicine is an open access, online journal publishing evidence-based, scientifically justified, and ethical research into all aspects of Chinese medicine. Areas of interest include recent advances in herbal medicine, clinical nutrition, clinical diagnosis, acupuncture, pharmaceutics, biomedical sciences, epidemiology, education, informatics, sociology, and psychology that are relevant and significant to Chinese medicine. Examples of research approaches include biomedical experimentation, high-throughput technology, clinical trials, systematic reviews, meta-analysis, sampled surveys, simulation, data curation, statistics, omics, translational medicine, and integrative methodologies. Chinese Medicine is a credible channel to communicate unbiased scientific data, information, and knowledge in Chinese medicine among researchers, clinicians, academics, and students in Chinese medicine and other scientific disciplines of medicine.