Determining the Feasibility of a Mail-In Saliva Sample Protocol for Persons Living with HIV in Two Urban Northeast United States Clinics.

IF 1.8 Q4 INFECTIOUS DISEASES

HIV AIDS-Research and Palliative Care Pub Date : 2025-10-02 eCollection Date: 2025-01-01 DOI:10.2147/HIV.S492850

Matthew D Mara, Cynthia Miguel, Nina H Lin, Curt G Beckwith, Michelle Henshaw

{"title":"Determining the Feasibility of a Mail-In Saliva Sample Protocol for Persons Living with HIV in Two Urban Northeast United States Clinics.","authors":"Matthew D Mara, Cynthia Miguel, Nina H Lin, Curt G Beckwith, Michelle Henshaw","doi":"10.2147/HIV.S492850","DOIUrl":null,"url":null,"abstract":"Background: Mail-in saliva samples are a participant-centered means of monitoring patients' oral and overall health that may help to reduce unnecessary medical trips and more efficiently use provider time. The use and acceptability of mail-in saliva samples have been studied in high-risk populations; however, it has not been studied in cohorts of people living with HIV (PLWH).Objective: To investigate the feasibility of PLWHs' willingness to provide mail-in saliva samples, 900 saliva collection kits were mailed to a randomized sample of PLWH across two urban and diverse clinics in the Northeast United States in 2019-2020.Results: 73/900 (8%) packages were returned to study personnel, with 100% (73/73) containing saliva deemed usable for analysis. 55/900 (6%) of packages were returned to the study team undeliverable. Further information may be gained from investigating the influence of personalized test results, health literacy, the requirement of the oral health survey, and study compensation that may affect an individual's motivation to participate in the study.Conclusion: While findings suggest limited feasibility of mail-in saliva collection without personalized test results in a cohort of PLWH in terms of response rate, all returned saliva samples were usable for analysis suggesting that addressing potential barriers may improve response rates and the feasibility of using mail-in salivary diagnostics to monitor disease progression in PLWH in future studies.","PeriodicalId":46555,"journal":{"name":"HIV AIDS-Research and Palliative Care","volume":"17 ","pages":"337-349"},"PeriodicalIF":1.8000,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12500845/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"HIV AIDS-Research and Palliative Care","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2147/HIV.S492850","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Mail-in saliva samples are a participant-centered means of monitoring patients' oral and overall health that may help to reduce unnecessary medical trips and more efficiently use provider time. The use and acceptability of mail-in saliva samples have been studied in high-risk populations; however, it has not been studied in cohorts of people living with HIV (PLWH).

Objective: To investigate the feasibility of PLWHs' willingness to provide mail-in saliva samples, 900 saliva collection kits were mailed to a randomized sample of PLWH across two urban and diverse clinics in the Northeast United States in 2019-2020.

Results: 73/900 (8%) packages were returned to study personnel, with 100% (73/73) containing saliva deemed usable for analysis. 55/900 (6%) of packages were returned to the study team undeliverable. Further information may be gained from investigating the influence of personalized test results, health literacy, the requirement of the oral health survey, and study compensation that may affect an individual's motivation to participate in the study.

Conclusion: While findings suggest limited feasibility of mail-in saliva collection without personalized test results in a cohort of PLWH in terms of response rate, all returned saliva samples were usable for analysis suggesting that addressing potential barriers may improve response rates and the feasibility of using mail-in salivary diagnostics to monitor disease progression in PLWH in future studies.

Abstract Image

查看原文本刊更多论文

在美国东北部的两个城市诊所确定邮寄唾液样本方案的可行性。

背景：邮寄唾液样本是一种以参与者为中心的监测患者口腔和整体健康的手段，可能有助于减少不必要的医疗旅行，更有效地利用医生的时间。在高危人群中研究了邮寄唾液样本的使用和可接受性；然而，尚未在艾滋病毒感染者（PLWH）群体中进行研究。目的：为了探讨PLWH提供邮寄唾液样本意愿的可行性，我们于2019-2020年将900个唾液收集包邮寄给美国东北部两个城市和不同诊所的PLWH随机样本。结果：73/900（8%）包被送回研究人员，其中100%（73/73）含唾液被认为可用于分析。55/900（6%）的包裹被退回给研究小组，无法投递。进一步的信息可以从调查个性化测试结果的影响、健康素养、口腔健康调查的要求以及可能影响个人参与研究动机的研究补偿中获得。结论：虽然研究结果表明，就应答率而言，在没有个性化检测结果的情况下，邮寄唾液收集在PLWH队列中的可行性有限，但所有返回的唾液样本都可用于分析，这表明解决潜在障碍可能会提高应答率，并且在未来的研究中，使用邮寄唾液诊断来监测PLWH疾病进展的可行性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

HIV AIDS-Research and Palliative Care INFECTIOUS DISEASES-

CiteScore

3.00

自引率

6.70%

发文量

审稿时长

16 weeks

期刊介绍： About Dove Medical Press Dove Medical Press Ltd is part of Taylor & Francis Group, the Academic Publishing Division of Informa PLC. We specialize in the publication of Open Access peer-reviewed journals across the broad spectrum of science, technology and especially medicine. Dove Medical Press was founded in 2003 with the objective of combining the highest editorial standards with the ''best of breed'' new publishing technologies. We have offices in Manchester and London in the United Kingdom, representatives in Princeton, New Jersey in the United States, and our editorial offices are in Auckland, New Zealand. Dr Scott Fraser is our Medical Director based in the UK. He has been in full time clinical practice for over 20 years as well as having an active research interest.