Vlasta Krausova, David Neumann, Lucie Stichova, Jaroslav Skvor, Vlasta Dostalova, Pavel Dostal
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引用次数: 0
Abstract
Introduction: Type 1 diabetes is commonly associated with microvascular complications. Sublingual microcirculation examination using sidestream dark-field (SDF) imaging can reflect the situation in visceral microcirculation. The main goals of this observational study were to assess the feasibility of SDF imaging in children with compensated type 1 diabetes, determine selected sublingual microcirculation parameters, and compare them with parameters obtained in healthy children.
Methods: In total 30 children with stable type 1 diabetes without clinical or laboratory signs of microvascular complications were included in the study, 15 males and 15 females in three age categories. Three video clips were recorded using an SDF probe from different parts of the sublingual area and analyzed by software-aided offline analysis.
Results: Videoclips were successfully recorded in all children. Compared with healthy children, the De Backer score (DeBS) in females and total vessel density (TVD), small vessel density (SVD), perfused vessel density (PVD), and perfused SVD (PSVD) in both genders were significantly lower in children with T1D. There were no differences in TVD, SVD, PVD, PSVD, and DeBS between age or gender categories. DeBS correlated with ketonemia; otherwise, no significant relationship was observed between microcirculatory and other recorded parameters.
Conslusions: Sublingual microcirculation examination using SDF imaging is feasible in children with type 1 diabetes. Alteration of sublingual microcirculatory parameters is detectable in children with type 1 diabetes before they show clinical or laboratory signs of any microvascular complication.
期刊介绍：
Pediatric Diabetes is a bi-monthly journal devoted to disseminating new knowledge relating to the epidemiology, etiology, pathogenesis, management, complications and prevention of diabetes in childhood and adolescence. The aim of the journal is to become the leading vehicle for international dissemination of research and practice relating to diabetes in youth. Papers are considered for publication based on the rigor of scientific approach, novelty, and importance for understanding mechanisms involved in the epidemiology and etiology of this disease, especially its molecular, biochemical and physiological aspects. Work relating to the clinical presentation, course, management and outcome of diabetes, including its physical and emotional sequelae, is considered. In vitro studies using animal or human tissues, whole animal and clinical studies in humans are also considered. The journal reviews full-length papers, preliminary communications with important new information, clinical reports, and reviews of major topics. Invited editorials, commentaries, and perspectives are a regular feature. The editors, based in the USA, Europe, and Australasia, maintain regular communications to assure rapid turnaround time of submitted manuscripts.
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