Association Between the CALLY Index and Kidney Stones: Insights From NHANES 2007-2010.

IF 4.2 3区医学 Q2 CELL BIOLOGY

Mediators of Inflammation Pub Date : 2025-09-30 eCollection Date: 2025-01-01 DOI:10.1155/mi/9920716

Liangliang Dai, Chenjie Qiu

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Abstract

Background: Kidney stones are a prevalent health concern with rising incidence, influenced by factors such as inflammation, nutrition, and immune function. The C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index-a composite measure of CRP, albumin, and lymphocyte count-has demonstrated prognostic value in several cancers. However, its relevance to kidney stone formation remains largely unexplored. This study aimed to examine the association between the CALLY index and kidney stone risk using data from the National Health and Nutrition Examination Survey (NHANES) 2007-2010.

Methods: A total of 10,562 participants were included after applying exclusion criteria. Kidney stone status was determined through self-reported questionnaires, and the CALLY index was calculated accordingly. Associations between the CALLY index and kidney stones were assessed using multivariable logistic regression, restricted cubic spline (RCS) models, and subgroup analyses.

Results: Participants with kidney stones exhibited a lower mean CALLY index. Multivariable analyses revealed a significant inverse association between the CALLY index and kidney stone risk, particularly when the index was modeled categorically. Individuals in the highest quartile of the CALLY index had a 27.3% lower risk of kidney stones compared with those in the lowest quartile. RCS analysis further confirmed a nonlinear relationship.

Conclusion: The findings suggest that the CALLY index is negatively associated with kidney stone risk.

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CALLY指数与肾结石之间的关系：来自NHANES 2007-2010的见解。

背景：肾结石是一种普遍的健康问题，发病率不断上升，受炎症、营养和免疫功能等因素的影响。c反应蛋白(CRP)-白蛋白淋巴细胞（CALLY）指数- CRP，白蛋白和淋巴细胞计数的复合测量-已经证明了几种癌症的预后价值。然而，它与肾结石形成的相关性在很大程度上仍未被探索。本研究旨在利用2007-2010年国家健康与营养检查调查（NHANES）的数据，检查CALLY指数与肾结石风险之间的关系。方法：采用排除标准，纳入10562例受试者。通过自述问卷确定肾结石状况，并计算CALLY指数。采用多变量logistic回归、限制性三次样条（RCS）模型和亚组分析评估CALLY指数与肾结石之间的关系。结果：肾结石患者的平均CALLY指数较低。多变量分析显示，CALLY指数与肾结石风险之间存在显著的负相关，特别是当该指数被分类建模时。CALLY指数最高的四分位数的人患肾结石的风险比最低的四分位数的人低27.3%。RCS分析进一步证实了非线性关系。结论：CALLY指数与肾结石风险呈负相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mediators of Inflammation 医学-免疫学

CiteScore

8.70

自引率

0.00%

发文量

202

审稿时长

4 months

期刊介绍： Mediators of Inflammation is a peer-reviewed, Open Access journal that publishes original research and review articles on all types of inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, leukotrienes, PAF, biological response modifiers and the family of cell adhesion-promoting molecules.