Jin Rong, Yuanhua Dai, Bo Zhang, Yuxi Li, Kexu Chen, Hanfei Li, Tingting Zhao, Shunmei Liu
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引用次数: 0
Abstract
Diabetic kidney disease (DKD) is closely linked to aging, with gut microbiota imbalance recognized as a key factor, making it a growing research focus. Studies have shown that gut dysbiosis in DKD patients is characterized by a reduction in beneficial bacteria and an overgrowth of opportunistic pathogens, leading to gut barrier disruption, systemic low-grade inflammation, oxidative stress, and accelerated fibrosis. The decrease in short-chain fatty acids (SCFAs) impairs epigenetic regulation, driving the overexpression of fibrosis-related genes. Aging itself also alters the composition of the gut microbiota, further exacerbating metabolic disorders and inflammation, thereby creating a vicious cycle. This article aims to explore the potential roles and mechanisms of gut microbiota in the shared pathogenesis of DKD and aging, providing a theoretical foundation for the development of novel therapeutic interventions.
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Life Sciences is an international journal publishing articles that emphasize the molecular, cellular, and functional basis of therapy. The journal emphasizes the understanding of mechanism that is relevant to all aspects of human disease and translation to patients. All articles are rigorously reviewed.
The Journal favors publication of full-length papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms. Articles that merely report observations are rarely accepted. Recommendations from the Declaration of Helsinki or NIH guidelines for care and use of laboratory animals must be adhered to. Articles should be written at a level accessible to readers who are non-specialists in the topic of the article themselves, but who are interested in the research. The Journal welcomes reviews on topics of wide interest to investigators in the life sciences. We particularly encourage submission of brief, focused reviews containing high-quality artwork and require the use of mechanistic summary diagrams.
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