Dynamic deuterium metabolic imaging in glioblastoma at 7T.

IF 2.5 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Magnetic Resonance Materials in Physics, Biology and Medicine Pub Date : 2025-10-09 DOI:10.1007/s10334-025-01299-3

Narjes Ahmadian, Mark Gosselink, Sigrid Otto, Dimitri Welting, Kiki Tesselaar, Tom Snijders, Pieter van Eijsden, Jeanine Prompers, Dennis Klomp, Evita Wiegers

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引用次数: 0

Abstract

Objective: This study investigates the dynamic metabolic characteristics of glioblastoma (GBM) using Deuterium Metabolic Imaging (DMI) at 7 T, aiming to dynamically characterize the Warburg effect in vivo.

Material and methods: Five newly diagnosed GBM patients underwent dynamic DMI prior to any treatment. 3D ²H free-induction-decay (FID)-Magnetic resonance spectroscopy imaging (MRSI) measurements (11:44 min per scan) were performed at 7 T during ~ 100 min following [6,6'-²H₂]glucose consumption. Venous plasma glucose and plasma ²H-Glc atom percent enrichment (APE) levels were measured during the scan. Brain ²H-glucose (²H-Glc),²H-Glutamate/Glutamine (²H-Glx), ²H-Lactate (²H-Lac), ²H-Lac/²H-Glx were analyzed with a two-level (time and tissue type) Linear Mixed Model.

Results: Brain ²H-Glc levels were similar across tissue types. ²H-Glx was significantly lower in tumors compared to normal appearing brain tissue (NABT) (p < 0.01). ²H-Lac was significantly higher in tumors compared to NABT (P < 0.01). The ²H-Lac/²H-Glx ratio provided tumor-specific contrast, starting 40-50 min post [6,6'-²H₂]glucose consumption. Venous plasma glucose and ²H-Glc APE increased within 50 min and venous ²H-Glc APE stabilized at ~ 60%.

Discussion: Dynamic DMI at 7 T reveals metabolic alterations in GBM, particularly through the ²H-Lac/²H-Glx ratio. This contrast was primarily driven by decreased ²H-Glx rather than profoundly increased ²H-Lac. These findings support the utility of DMI in assessing metabolic reprogramming in brain tumors.

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胶质母细胞瘤7T时的动态氘代谢成像。

目的：本研究采用7 T氘代谢成像（DMI）技术研究胶质母细胞瘤（GBM）的动态代谢特征，旨在动态表征体内Warburg效应。材料和方法：5例新诊断的GBM患者在任何治疗之前都进行了动态DMI。3D 2H自由诱导衰变(FID)-磁共振波谱成像（MRSI）测量（每次扫描11:44分钟）在[6,6'-2H2]葡萄糖消耗后约100分钟内进行7t。在扫描过程中测量静脉血浆葡萄糖和血浆2H-Glc原子百分比富集（APE）水平。采用双水平（时间和组织类型）线性混合模型分析脑2h -葡萄糖（2H-Glc）、2h -谷氨酸/谷氨酰胺（2H-Glx）、2h -乳酸（2H-Lac）、2H-Lac/2H-Glx。结果：脑2H-Glc水平在不同组织类型中相似。与正常脑组织（NABT）相比，2H-Glx在肿瘤中的含量明显降低(p 2H-Lac在肿瘤中的含量明显高于NABT (p 2H-Lac/2H-Glx比值提供了肿瘤特异性对比，在[6,6'-2H2]葡萄糖消耗后40-50分钟开始。静脉血浆葡萄糖和2H-Glc APE在50min内升高，2H-Glc APE稳定在~ 60%。讨论：7 T时的动态DMI揭示了GBM的代谢改变，特别是通过2H-Lac/2H-Glx比率。这种对比主要是由于2H-Glx的减少而不是2H-Lac的显著增加。这些发现支持DMI在评估脑肿瘤代谢重编程中的效用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Magnetic Resonance Materials in Physics, Biology and Medicine 医学-核医学

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： MAGMA is a multidisciplinary international journal devoted to the publication of articles on all aspects of magnetic resonance techniques and their applications in medicine and biology. MAGMA currently publishes research papers, reviews, letters to the editor, and commentaries, six times a year. The subject areas covered by MAGMA include: advances in materials, hardware and software in magnetic resonance technology, new developments and results in research and practical applications of magnetic resonance imaging and spectroscopy related to biology and medicine, study of animal models and intact cells using magnetic resonance, reports of clinical trials on humans and clinical validation of magnetic resonance protocols.