Considerations for Treating Generalized Pustular Psoriasis (GPP): A Narrative Review.

IF 4.2 3区医学 Q1 DERMATOLOGY

Dermatology and Therapy Pub Date : 2025-10-09 DOI:10.1007/s13555-025-01535-7

Charles W Lynde, Vimal H Prajapati, Melinda J Gooderham, H Chih-Ho Hong, Mark G Kirchhof, Perla Lansang, Julien Ringuet, Irina Turchin, Ron Vender, Jensen Yeung, Kim A Papp

引用次数: 0

Abstract

Generalized pustular psoriasis (GPP) is a rare, chronic dermatological condition characterized by widespread pustulation that may be associated with other cutaneous and systemic manifestations. If left untreated, it may be life-threatening. Therapies developed for plaque psoriasis have been used to treat GPP with limited efficacy; however, these therapies do not target the interleukin (IL)-36 pathway, which is the most common pathway implicated in the pathogenesis of GPP. A systemic biologic targeting the IL-36 receptor for the treatment of GPP is currently the only approved treatment for GPP and allows for an opportunity to improve patient outcomes. This manuscript outlines practical considerations that aim to provide guidance on personalizing the treatment of GPP.

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治疗广泛性脓疱性银屑病（GPP）的注意事项：叙述回顾。

广泛性脓疱性牛皮癣（GPP）是一种罕见的慢性皮肤病，其特征是广泛的脓疱，可能与其他皮肤和全身表现有关。如果不及时治疗，可能会危及生命。为斑块型银屑病开发的治疗方法已用于治疗GPP，但疗效有限；然而，这些疗法并不针对白细胞介素(IL)-36途径，这是GPP发病机制中最常见的途径。靶向IL-36受体的系统性生物制剂治疗GPP是目前唯一被批准的GPP治疗方法，有机会改善患者的预后。这份手稿概述了实际的考虑，旨在为个性化治疗GPP提供指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dermatology and Therapy Medicine-Dermatology

CiteScore

6.00

自引率

8.80%

发文量

187

审稿时长

6 weeks

期刊介绍： Dermatology and Therapy is an international, open access, peer-reviewed, rapid publication journal (peer review in 2 weeks, published 3–4 weeks from acceptance). The journal is dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of dermatological therapies. Studies relating to diagnosis, pharmacoeconomics, public health and epidemiology, quality of life, and patient care, management, and education are also encouraged. Areas of focus include, but are not limited to all clinical aspects of dermatology, such as skin pharmacology; skin development and aging; prevention, diagnosis, and management of skin disorders and melanomas; research into dermal structures and pathology; and all areas of aesthetic dermatology, including skin maintenance, dermatological surgery, and lasers. The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/case series, trial protocols, and short communications. Dermatology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an International and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of quality research, which may be considered of insufficient interest by other journals. The journal appeals to a global audience and receives submissions from all over the world.