⁶⁸Ga-DOTATATE Measurements Predict Progression of Aortic Valve Calcification in Humans.

IF 7.4 1区医学 Q1 HEMATOLOGY

Arteriosclerosis, Thrombosis, and Vascular Biology Pub Date : 2025-10-09 DOI:10.1161/ATVBAHA.125.322779

Wesam Aldosoky, Shady Abohashem, Guillaume Goudot, Simran S Grewal, Iqra Qamar, Erin Hanlon, Omar Alani, Jamie Bellinge, Giovanni Civieri, Michael T Osborne, Marc R Dweck, Pedram Heidari, Ahmed Tawakol

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引用次数: 0

Abstract

Background: Inflammation potentiates aortic valve calcification (AVC). Gallium dodecane tetraacetic acid-Tyr3-octreotate (⁶⁸Ga-DOTATATE), a positron emission tomography tracer that binds to somatostatin receptors, provides a measure of tissue inflammation. However, the diagnostic and prognostic values of aortic valve (AV) ⁶⁸Ga-DOTATATE uptake in AVC remain unexplored. Here, we tested whether AV ⁶⁸Ga-DOTATATE uptake predicts the progression of AVC.

Methods: A total of 683 individuals (median age, 63 years; 46% male) underwent clinical ⁶⁸Ga-DOTATATE positron emission tomography/computed tomography imaging from 2017 to 2023; 209 had follow-up imaging (median, 1.3 years interval). AV inflammation was measured as the maximum standardized uptake value of ⁶⁸Ga-DOTATATE uptake within the AV on baseline positron emission tomography/computed tomography. AVC was quantified on baseline and follow-up computed tomography scans (Hounsfield units >130). AVC progression was assessed as the difference between baseline and follow-up AVC. Individuals with a square root difference of annualized AVC change ≥2.5 were characterized as progressors and <2.5 as nonprogressors. Demographic and clinical data were collected from medical records.

Results: Baseline AV ⁶⁸Ga-DOTATATE uptake correlated with baseline AVC (standardized ρ=0.12; P=0.002). Furthermore, baseline AV ⁶⁸Ga-DOTATATE uptake associated with AVC progression (odds ratio [OR], 3.0 [95% CI, 1.4-6.4]; P=0.004) and remained significant after separately adjusting for baseline AVC (OR, 3.1 [95% CI, 1.5-6.6]), sex (OR, 4.0 [95% CI, 1.7-9.0]), hypertension (OR, 2.8 [95% CI, 1.3-6.2]), diabetes (OR, 3.0 [95% CI, 1.4-6.4]), hyperlipidemia (OR, 2.4 [95% CI, 1.1-5.3]), smoking (OR, 3.1 [95% CI, 1.5-6.7]), chronic kidney disease (OR, 2.9 [95% CI, 1.4-6.3]), and body mass index (OR, 3.0 [95% CI, 1.4-6.3]), became insignificant when adjusting to age (OR, 1.9 [95% CI, 0.8-4.3]).

Conclusions: Our study highlights the use of ⁶⁸Ga-DOTATATE for assessing AV inflammation and predicting AVC progression. These findings underscore the role of inflammation in AVC progression and have potential implications for risk assessment and evaluating therapies in AV disease.

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68Ga-DOTATATE测量可预测人类主动脉瓣钙化的进展。

背景：炎症增强主动脉瓣钙化（AVC）。十二烷四乙酸- tyr3 -octreotate镓（68Ga-DOTATATE）是一种结合生长抑素受体的正电子发射断层扫描示踪剂，可用于测量组织炎症。然而，主动脉瓣（AV） 68Ga-DOTATATE摄取在AVC中的诊断和预后价值仍未得到探讨。在这里，我们测试了AV 68Ga-DOTATATE摄取是否能预测AVC的进展。方法：2017 - 2023年，683例患者（中位年龄63岁，46%男性）接受了68Ga-DOTATATE正电子发射断层扫描/计算机断层扫描；209例随访影像（中位数，间隔1.3年）。在基线正电子发射断层扫描/计算机断层扫描上，以AV内68Ga-DOTATATE摄取的最大标准化摄取值来测量AV炎症。通过基线和随访计算机断层扫描（Hounsfield单位>130）对AVC进行量化。评估AVC进展为基线和随访AVC之间的差异。AVC年化变化平方根差≥2.5的个体为进展者。结果：基线AVC 68Ga-DOTATATE摄取与基线AVC相关（标准化ρ=0.12； P=0.002）。此外，基线AV 68Ga-DOTATATE摄取与AVC进展相关(优势比[OR]， 3.0 [95% CI, 1.4-6.4]；P=0.004)，在分别调整基线AVC （OR, 3.1 [95% CI, 1.5-6.6]）、性别（OR, 4.0 [95% CI, 1.7-9.0]）、高血压（OR, 2.8 [95% CI, 1.3-6.2]）、糖尿病（OR, 3.0 [95% CI, 1.4-6.4]）、高脂血症（OR, 2.4 [95% CI, 1.1-5.3]）、吸烟（OR, 3.1 [95% CI, 1.5-6.7]）、慢性肾脏疾病（OR, 2.9 [95% CI, 1.4-6.3]）和体重指数（OR, 3.0 [95% CI, 1.4-6.3]）后，当调整到年龄（OR, 1.9 [95% CI, 0.8-4.3]）时变得不显著。结论：我们的研究强调了68Ga-DOTATATE在评估AVC炎症和预测AVC进展方面的应用。这些发现强调了炎症在AVC进展中的作用，并对AVC疾病的风险评估和治疗评估具有潜在的意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Arteriosclerosis, Thrombosis, and Vascular Biology 医学-外周血管病

CiteScore

15.60

自引率

2.30%

发文量

337

审稿时长

2-4 weeks

期刊介绍： The journal "Arteriosclerosis, Thrombosis, and Vascular Biology" (ATVB) is a scientific publication that focuses on the fields of vascular biology, atherosclerosis, and thrombosis. It is a peer-reviewed journal that publishes original research articles, reviews, and other scholarly content related to these areas. The journal is published by the American Heart Association (AHA) and the American Stroke Association (ASA). The journal was published bi-monthly until January 1992, after which it transitioned to a monthly publication schedule. The journal is aimed at a professional audience, including academic cardiologists, vascular biologists, physiologists, pharmacologists and hematologists.