Stability and Adaptation of Proteins, Membranes and Cells to Extreme Temperature and Pressure

IF 4.7 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Molecular Biology Pub Date : 2026-02-15 Epub Date: 2025-10-06 DOI:10.1016/j.jmb.2025.169477

J. Peters , J.G. LoRicco , M. Saracco , A. Caliò , P. Oger

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Abstract

All biological systems, from low complexity (single molecules) to high complexity (whole cells), must find a way to maintain stability and function under a wide array of environmental conditions. Archaea have been found to be particularly effective at inhabiting the most extreme environments found on Earth. Proto-cells at the origin of life are hypothesised to have originated under even harsher conditions. Therefore, in this review, we summarise our recent works which have provided insights into the molecular bases for adaptation in various archaeal and proto-cell systems, to temperature and high hydrostatic pressure. First, we discuss adaptation in archaeal membranes, which differ significantly from membranes of Bacteria and eukaryotes, having been adapted by evolution to extreme environments. Next, we consider how functionality could have arisen and been maintained in simple proto-membranes. Finally, we discuss proteome and cell-wide adaptation strategies seen in adapted vs non-adapted species.

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蛋白质、膜和细胞对极端温度和压力的稳定性和适应性。

所有生物系统，从低复杂性（单分子）到高复杂性（整个细胞），都必须找到一种在各种环境条件下保持稳定性和功能的方法。人们发现古细菌在地球上最极端的环境中生存得特别有效。据推测，生命起源时的原始细胞是在更为恶劣的条件下产生的。因此，在本文中，我们总结了我们最近的研究成果，为各种古细菌和原细胞系统适应温度和高静水压力的分子基础提供了见解。首先，我们讨论了古细菌膜的适应性，它与细菌和真核生物的膜有很大的不同，它们通过进化适应了极端环境。接下来，我们考虑功能是如何在简单的原膜中产生和维持的。最后，我们讨论了在适应和非适应物种中观察到的蛋白质组和细胞范围的适应策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Molecular Biology 生物-生化与分子生物学

CiteScore

11.30

自引率

1.80%

发文量

412

审稿时长

28 days

期刊介绍： Journal of Molecular Biology (JMB) provides high quality, comprehensive and broad coverage in all areas of molecular biology. The journal publishes original scientific research papers that provide mechanistic and functional insights and report a significant advance to the field. The journal encourages the submission of multidisciplinary studies that use complementary experimental and computational approaches to address challenging biological questions. Research areas include but are not limited to: Biomolecular interactions, signaling networks, systems biology; Cell cycle, cell growth, cell differentiation; Cell death, autophagy; Cell signaling and regulation; Chemical biology; Computational biology, in combination with experimental studies; DNA replication, repair, and recombination; Development, regenerative biology, mechanistic and functional studies of stem cells; Epigenetics, chromatin structure and function; Gene expression; Membrane processes, cell surface proteins and cell-cell interactions; Methodological advances, both experimental and theoretical, including databases; Microbiology, virology, and interactions with the host or environment; Microbiota mechanistic and functional studies; Nuclear organization; Post-translational modifications, proteomics; Processing and function of biologically important macromolecules and complexes; Molecular basis of disease; RNA processing, structure and functions of non-coding RNAs, transcription; Sorting, spatiotemporal organization, trafficking; Structural biology; Synthetic biology; Translation, protein folding, chaperones, protein degradation and quality control.