Structure of trans,trans-[Pt(py)2(N3)2(OH)2]·2H2O and Synthesis of Pt(IV) Prodrugs Based on It

IF 1.4 4区化学 Q4 CHEMISTRY, INORGANIC & NUCLEAR

Journal of Structural Chemistry Pub Date : 2025-10-09 DOI:10.1134/S0022476625090057

A. E. Zazulya, P. A. Abramov, S. V. Tkachev, D. G. Sheven’, A. Yu. Komarovskikh, P. E. Plyusnin, D. B. Vasilchenko

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Abstract

The structure of trans,trans-[Pt(py)₂(N₃)₂(OH)₂]·2H₂O is studied by single crystal X-ray diffraction. The crystallographic data are: a = 9.8240(2) Å, b = 17.2178(3) Å, c = 9.5248(2) Å, β = 97.777(1)°, space group P2₁/c, Z = 4, ρ_cal = 2.11 g/cm³. The crystal structure of the complex consists of molecular layers perpendicular to the c direction. The transformation process of the dehydrate to the anhydrous complex is analyzed by thermal gravimetry. The previously published synthesis procedures of trans,trans-[Pt(py)₂(N₃)₂(OH)(SuccH)] and trans,trans-[Pt(py)₂(N₃)₂(OH)(Succ-NH-TEMPO)] complexes from trans,trans-[Pt(py)₂(N₃)₂(OH)₂] are modified. The optimization of synthesis conditions and the product isolation procedure increases the product yield and substantially improves the purity of the obtained compounds.

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反式、反式-[Pt(py)2(N3)2(OH)2]·2H2O的结构及基于它的Pt（IV）前药的合成

用单晶x射线衍射研究了反式，反式-[Pt(py)2(N3)2(OH)2]·2H2O的结构。晶体数据:= 9.8240 (2)a, b = 17.2178 (3) a, c = 9.5248(2),β= 97.777(1)°,空间群P21 / c、Z = 4,ρ卡尔= 2.11克/立方厘米。该配合物的晶体结构由垂直于c方向的分子层组成。用热重法分析了脱水产物向无水络合物的转变过程。对先前发表的由trans，trans-[Pt(py)2(N3)2(OH)2]合成的trans，trans-[Pt(py)2(N3)2(OH)2]和trans，trans-[Pt(py)2(N3)2(OH)2] (ske - nh - tempo)]配合物进行了改进。合成条件和产物分离工艺的优化提高了产物得率，大大提高了所得化合物的纯度。

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来源期刊

Journal of Structural Chemistry 化学-无机化学与核化学

CiteScore

1.60

自引率

12.50%

发文量

142

审稿时长

8.3 months

期刊介绍： Journal is an interdisciplinary publication covering all aspects of structural chemistry, including the theory of molecular structure and chemical bond; the use of physical methods to study the electronic and spatial structure of chemical species; structural features of liquids, solutions, surfaces, supramolecular systems, nano- and solid materials; and the crystal structure of solids.