Systematic review: digital biomarkers of fatigue in chronic diseases.

IF 15.1 1区医学 Q1 HEALTH CARE SCIENCES & SERVICES

NPJ Digital Medicine Pub Date : 2025-10-08 DOI:10.1038/s41746-025-01939-x

Nana Yaw Aboagye,Chloe Hinchliffe,Silvia Del Din,Wan-Fai Ng,Kenneth F Baker,Mark R Baker

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Abstract

This systematic review explores the relationship between digital biomarkers, measured using wearable devices, and fatigue in patients with chronic diseases. Studies included in this review focused on individuals with diseases or conditions in 13 broad categories: multiple sclerosis (MS); rheumatoid arthritis (RA); chronic obstructive pulmonary disease (COPD); long COVID; cancer; chronic fatigue syndrome (CFS); pulmonary sarcoidosis; Parkinson's disease; chronic stroke; chronic inflammatory rheumatic disease (CIRD); Inflammatory Bowel Diseases (IBD), Primary Sjogren's Syndrome (PSS), and Systemic Lupus Erythematosus (SLE). The review synthesizes findings on the correlation between objective digital biomarkers and self-reported fatigue, highlighting the potential for disease-specific digital biomarkers to inform personalized fatigue management. The results suggest that reduced physical activity, increased sedentary behavior and autonomic dysfunction are associated with fatigue levels across multiple disease conditions included in this review, though the strength of this association and the specific biomarkers involved vary across diseases.

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系统综述：慢性疾病中疲劳的数字生物标志物。

本系统综述探讨了使用可穿戴设备测量的数字生物标志物与慢性疾病患者疲劳之间的关系。本综述纳入的研究集中于13大类疾病或病症患者：多发性硬化症（MS）；类风湿性关节炎；慢性阻塞性肺病（COPD）；长COVID;癌症;慢性疲劳综合征（CFS）；肺结节病;帕金森病;慢性中风;慢性炎性风湿病（CIRD）；炎症性肠病（IBD）、原发性干燥综合征（PSS）和系统性红斑狼疮（SLE）。该综述综合了客观数字生物标志物与自我报告疲劳之间的相关性，强调了疾病特异性数字生物标志物为个性化疲劳管理提供信息的潜力。结果表明，体力活动减少、久坐行为增加和自主神经功能障碍与本综述中包括的多种疾病的疲劳水平有关，尽管这种关联的强度和所涉及的特定生物标志物因疾病而异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NPJ Digital Medicine Multiple-

CiteScore

25.10

自引率

3.30%

发文量

170

审稿时长

15 weeks

期刊介绍： npj Digital Medicine is an online open-access journal that focuses on publishing peer-reviewed research in the field of digital medicine. The journal covers various aspects of digital medicine, including the application and implementation of digital and mobile technologies in clinical settings, virtual healthcare, and the use of artificial intelligence and informatics. The primary goal of the journal is to support innovation and the advancement of healthcare through the integration of new digital and mobile technologies. When determining if a manuscript is suitable for publication, the journal considers four important criteria: novelty, clinical relevance, scientific rigor, and digital innovation.