The prevalence of diabetic neuropathy in Greenland and its association with Inuit genetic ancestry - a cross-sectional study.

IF 3.1 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Journal of diabetes and its complications Pub Date : 2025-10-02 DOI:10.1016/j.jdiacomp.2025.109179

Marie Mathilde Bjerg Christensen, Christian Stevns Hansen, Jesper Fleischer, Ninna Senftleber, Frederik Filip Stæger, Torben Hansen, Daniel R Witte, Marit Eika Jørgensen

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Abstract

Aims: Data on diabetic neuropathies in Greenland remains limited. The aim was to estimate the prevalence of diabetic peripheral neuropathy (DPN) and cardiovascular autonomic neuropathy (CAN) among Greenlanders with diabetes and prediabetes and investigate whether Inuit ancestry contributes to higher susceptibility.

Methods: Individuals with diabetes and prediabetes from the Greenland Population Survey 2018 were examined for DPN (Vibration Perception Threshold (VPT) and light pressure) and CAN (Cardiovascular Reflex Tests and Heart Rate Variability). Inuit genetic admixture was included as a determinant in regression models adjusted for age, sex, genetics, diabetes status and residency.

Results: Among 447 participants (1/3 diabetes, median age 61, 57 % female) DPN prevalence was 28 % in diabetes and 25 % in prediabetes. CAN prevalence was 24 % and 15 %, respectively. A 20-percentage point change in Inuit ancestry was associated with a 4 % higher VPT (coefficient: 1.04, 95 % CI: 1.003-1.08) and 51 % higher odds of CAN (OR: 1.51, 95 % CI: 1.09-2.08).

Conclusions: DPN and CAN are common among Greenlanders with diabetes and prediabetes, highlighting the need for improved diagnostics and prevention. The association between Inuit genetic ancestry and neuropathy suggests a predisposition to neuropathy among Inuit, which may be explained by both genetic and lifestyle factors.

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格陵兰岛糖尿病神经病变的患病率及其与因纽特人遗传祖先的关系-一项横断面研究。

目的：格陵兰岛糖尿病神经病变的数据仍然有限。目的是估计格陵兰人糖尿病和前驱糖尿病患者中糖尿病周围神经病变（DPN）和心血管自主神经病变（CAN）的患病率，并调查因纽特人血统是否导致更高的易感性。方法：对2018年格陵兰人口调查中患有糖尿病和前驱糖尿病的个体进行DPN（振动感知阈值（VPT）和光压）和CAN（心血管反射试验和心率变异性）检查。因纽特人的遗传混合被包括在年龄、性别、遗传、糖尿病状况和居住地调整的回归模型中作为决定因素。结果：在447名参与者中（1/3的糖尿病患者，中位年龄61岁，57%的女性），DPN患病率为28%的糖尿病和25%的前驱糖尿病。CAN患病率分别为24%和15%。因纽特人祖先中20个百分点的变化与4%的VPT升高（系数：1.04,95% CI: 1.003-1.08）和51%的CAN几率升高（OR: 1.51, 95% CI: 1.09-2.08）相关。结论：DPN和CAN在格陵兰岛糖尿病和前驱糖尿病患者中很常见，强调了改进诊断和预防的必要性。因纽特人的遗传血统与神经病变之间的联系表明，因纽特人易患神经病变，这可能由遗传和生活方式因素来解释。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of diabetes and its complications 医学-内分泌学与代谢

CiteScore

5.90

自引率

3.30%

发文量

153

审稿时长

16 days

期刊介绍： Journal of Diabetes and Its Complications (JDC) is a journal for health care practitioners and researchers, that publishes original research about the pathogenesis, diagnosis and management of diabetes mellitus and its complications. JDC also publishes articles on physiological and molecular aspects of glucose homeostasis. The primary purpose of JDC is to act as a source of information usable by diabetes practitioners and researchers to increase their knowledge about mechanisms of diabetes and complications development, and promote better management of people with diabetes who are at risk for those complications. Manuscripts submitted to JDC can report any aspect of basic, translational or clinical research as well as epidemiology. Topics can range broadly from early prediabetes to late-stage complicated diabetes. Topics relevant to basic/translational reports include pancreatic islet dysfunction and insulin resistance, altered adipose tissue function in diabetes, altered neuronal control of glucose homeostasis and mechanisms of drug action. Topics relevant to diabetic complications include diabetic retinopathy, neuropathy and nephropathy; peripheral vascular disease and coronary heart disease; gastrointestinal disorders, renal failure and impotence; and hypertension and hyperlipidemia.