Constructing a novel mitochondrial-related gene signature for predicting survival and evaluating the tumor immune microenvironment in clear cell renal cell carcinoma.

IF 2.8 3区生物学 Q2 GENETICS & HEREDITY

Frontiers in Genetics Pub Date : 2025-09-22 eCollection Date: 2025-01-01 DOI:10.3389/fgene.2025.1543593

Jiaxuan Qin, Lijian Zhang, Bowen Chen

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引用次数: 0

Abstract

Background: Mitochondria play an important role in tumors. Cellular energy supply, signaling, metabolism, autophagy, aging, and tumorigenesis are all associated with mitochondria. However, we lack a reliable prognostic model using mitochondrial-related genes in clear cell renal cell carcinoma (ccRCC).

Methods: A systematic analysis of available TCGA databases and related studies was conducted using the R language and online analysis tools to evaluate the prognostic value of mitochondrial-related genes and the tumor microenvironment in ccRCC.

Results: We constructed a novel mitochondrial-related gene signature for predicting survival and evaluating the tumor immune microenvironment in ccRCC. The mitochondrial-related gene signature included MICALL2, FKBP10, and ACADSB. According to the risk score of the risk model, ccRCC patients were divided into high- or low-risk groups. The ccRCC high-risk group with a high-risk score is related to poor prognosis and poor efficacy from immune checkpoint inhibitors (ICIs).

Conclusion: Our mitochondrial-related gene signature, as a risk model, could be a reliable ccRCC prognostic biomarker and could predict the response to immunotherapy. The risk score was correlated with the tumor microenvironment and immune cell infiltration.

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构建新的线粒体相关基因标记以预测透明细胞肾细胞癌的生存和评估肿瘤免疫微环境。

背景：线粒体在肿瘤中起重要作用。细胞的能量供应、信号传导、代谢、自噬、衰老和肿瘤发生都与线粒体有关。然而，我们缺乏使用线粒体相关基因在透明细胞肾细胞癌（ccRCC）中的可靠预后模型。方法：利用R语言和在线分析工具，系统分析现有TCGA数据库及相关研究，评价线粒体相关基因和肿瘤微环境在ccRCC中的预后价值。结果：我们构建了一个新的线粒体相关基因标记，用于预测ccRCC的生存和评估肿瘤免疫微环境。线粒体相关基因包括MICALL2、FKBP10和ACADSB。根据风险模型的风险评分，将ccRCC患者分为高危组和低危组。高危评分的ccRCC高危组与免疫检查点抑制剂（ICIs）预后差、疗效差相关。结论：我们的线粒体相关基因标记作为一种风险模型，可以作为可靠的ccRCC预后生物标志物，并可以预测免疫治疗的反应。风险评分与肿瘤微环境和免疫细胞浸润相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Genetics Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

5.50

自引率

8.10%

发文量

3491

审稿时长

14 weeks

期刊介绍： Frontiers in Genetics publishes rigorously peer-reviewed research on genes and genomes relating to all the domains of life, from humans to plants to livestock and other model organisms. Led by an outstanding Editorial Board of the world’s leading experts, this multidisciplinary, open-access journal is at the forefront of communicating cutting-edge research to researchers, academics, clinicians, policy makers and the public. The study of inheritance and the impact of the genome on various biological processes is well documented. However, the majority of discoveries are still to come. A new era is seeing major developments in the function and variability of the genome, the use of genetic and genomic tools and the analysis of the genetic basis of various biological phenomena.