SNRPB promotes gastric cancer progression by regulating aberrant splicing of PUF60.

IF 9.6 1区生物学 Q1 CELL BIOLOGY

Cell Death & Disease Pub Date : 2025-10-07 DOI:10.1038/s41419-025-08011-2

Dan Xiang, Jiaxin Yang, Miaofang Xiao, Cong Long, Yangxuan Lin, Chenchen Mao, Xin Liu, Dianfeng Mei, Wangkai Xie, Zheng Han, Chenbin Chen, Xiaoming Lin, Xian Shen, Xiangyang Xue, Tanzhou Chen

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引用次数: 0

Abstract

Alternative splicing is a pivotal regulatory mechanism in cellular biology that critically influences the tumorigenesis, progression, and phenotypic diversity of cancer. This study aimed to assess the intricate details and regulatory mechanisms of alternative splicing in gastric cancer. We constructed a comprehensive map of aberrant alternative splicing events in gastric cancer through bioinformatic analysis of public databases and clinical samples. Our study identified many abnormal splicing events in gastric cancer tissues, with exon skipping being the most frequent event. SNRPB, a key spliceosome component and principal splicing factor, was associated with the aberrant splicing of numerous splicing factors and oncogenes, influencing the p53 signaling pathway in the development and progression of gastric cancer. SNRPB directly regulates the selective splicing of TP53 by modulating its downstream factor, PUF60, thus facilitating the initiation and progression of gastric cancer. Therefore, SNRPB overexpression is linked to poor prognosis in gastric cancer and is a potential biomarker and therapeutic target.

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SNRPB通过调节PUF60的异常剪接促进胃癌的进展。

选择性剪接是细胞生物学中关键的调控机制，对肿瘤的发生、进展和表型多样性具有重要影响。本研究旨在评估胃癌中选择性剪接的复杂细节和调控机制。我们通过对公共数据库和临床样本的生物信息学分析，构建了胃癌异常选择性剪接事件的综合图谱。我们的研究在胃癌组织中发现了许多异常剪接事件，其中外显子跳跃是最常见的事件。SNRPB是关键剪接体组分和主要剪接因子，与多种剪接因子和癌基因的异常剪接相关，影响p53信号通路在胃癌发生发展中的作用。SNRPB通过调节TP53下游因子PUF60，直接调控TP53的选择性剪接，从而促进胃癌的发生和发展。因此，SNRPB过表达与胃癌预后不良有关，是一种潜在的生物标志物和治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Death & Disease CELL BIOLOGY-

CiteScore

15.10

自引率

2.20%

发文量

935

审稿时长

2 months

期刊介绍： Brought to readers by the editorial team of Cell Death & Differentiation, Cell Death & Disease is an online peer-reviewed journal specializing in translational cell death research. It covers a wide range of topics in experimental and internal medicine, including cancer, immunity, neuroscience, and now cancer metabolism. Cell Death & Disease seeks to encompass the breadth of translational implications of cell death, and topics of particular concentration will include, but are not limited to, the following: Experimental medicine Cancer Immunity Internal medicine Neuroscience Cancer metabolism